134777-63-2Relevant academic research and scientific papers
SYNTHESIS AND SOME CONVERSIONS OF 6-METHYL- AND 1,6-DIMETHYL-5-NITRO-4-PHENYL-2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINES
Remennikov, G. Ya.,Boldyrev, I. V.,Kapran, N. A.,Kurilenko, L. K.
, p. 325 - 329 (1993)
Using a modification of the Biginelli reaction, we have synthesized 6-methyl- and 1,6-dimethyl-5-nitro-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidines. We have studied some of their chemical conversions involving the methyl group on the C(6) atom, the nitrogen atoms of the pyrimidine ring, and the phenyl substituent.
Synthesis And Some Conversions Of 4-Aryl-6-Methyl-2-Methoxy(Phenyl)-5-Nitro-1,4-Dihydropyrimidines
Remennikov, G. Ya.,Boldyrev, I. V.,Kravchenko, S. A.,Pirozhenko, V. V.
, p. 1200 - 1205 (2007/10/02)
The reaction of 1-arylidene-1-nitropropan-2-ones with O-methylisourea (or benzamidine) in the presence of aluminum oxide gave 4-aryl-6-methyl-2-methoxy(phenyl)-5-nitro-1,4-dihydropyrimidines.It was shown that the reactions of the compounds synthesized with electrophilic agents proceed at the exocyclic methyl group, as well as at the N(1), N(3), and C(5) atoms of the 1,4-dihydropyrimidine fragment of the molecule.
