13479-88-4

Basic information

• Product Name: 5,7-dichlorothiazolo[5,4-d]pyrimidine
• Synonyms: 5,7-dichlorothiazolo[5,4-d]pyrimidine;5,7-dichloro-[1,3]thiazolo[5,4-d]pyriMidine
• CAS NO: 13479-88-4
• Molecular Formula: C₅HCl₂N₃S
• Molecular Weight: 206.05
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 13479-88-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 148.5-149.5 °C
• Boiling Point: 281.2 °C at 760 mmHg
• Flash Point: 123.9 °C
• Appearance: /
• Density: 1.767 g/cm³
• Vapor Pressure: 0.00615mmHg at 25°C
• Refractive Index: 1.73
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.68±0.50(Predicted)
• CAS DataBase Reference: 5,7-dichlorothiazolo[5,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dichlorothiazolo[5,4-d]pyrimidine(13479-88-4)
• EPA Substance Registry System: 5,7-dichlorothiazolo[5,4-d]pyrimidine(13479-88-4)

Safety Data

• Hazardous Substances Data: 13479-88-4(Hazardous Substances Data)

Usage

Uses

5,7-Dichlorothiazolo[5,4-d]pyrimidine was used in studies to prepare Kinase inhibitors.

InChI:InChI=1/C5HCl2N3S/c6-3-2-4(11-1-8-2)10-5(7)9-3/h1H

Upstream product

• 5082-82-6 4H-thiazolo[5,4-d]pyrimidine-5,7-dione 
• 5082-82-6 thiazolo[5,4-d]pyrimidine-5,7-(4H,6H)-dione 
• 5021-69-2 (4-carbamoylthiazol-5-yl)carbamic acid ethyl ester 
• 1394941-05-9 ethyl 5-((ethoxycarbonyl)amino)thiazole-4-carboxylate 

Downstream Products

• 41975-14-8 5-chloro-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine 
• 1093075-03-6 5-chloro-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine-2-carbaldehyde 
• 1542711-03-4 C₁₈H₁₆N₆S 
• 1542704-23-3 N-benzyl-5-(2-methoxy-1H-benzo[d]imidazol-1-yl)thiazolo[5,4-d]pyrimidin-7-amine 
• 1542711-02-3 N-benzyl-5-chlorothiazolo[5,4-d]pyrimidin-7-amine 
• 1401461-06-0 [1,4]diazepan-1-yl-{3-[7-(3,4-dimethoxy-phenylamino)thiazolo[5,4-d]pyrimidin-5-yl]phenyl}methanone hydrochloride 

Relevant articles and documents

SUBSTITUTED BICYCLIC PYRIMIDINE-BASED COMPOUNDS AND COMPOSITIONS AND USES THEREOF

Novel C-2-substituted bicyclic compounds of Formula I have been prepared and found to be useful as potent inhibitors of hGGPPS by inhibiting geranylgeranylation of proteins and inhibiting the biosynthesis of GGPP. The application is directed to these compounds, to compositions comprising these compounds, and to their use, in particular as medicaments for use in the treatment of cancer and other conditions which are treatable by inhibiting human geranylgeranylation pyrophosphate hGGPPS activity.

IRAK INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Convenient synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine

A convenient synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine is reported. The condensation of ethyl isocyanoacetate and ethoxycarbonyl isothiocyanate selectively gave the key 5-aminothiazole intermediate in high yield under mild conditions. This interm