5082-82-6

Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione is utilized as a key building block in the synthesis of various bioactive compounds and pharmaceuticals. Its unique structure and reactivity make it a valuable component in the creation of new drugs with a wide range of therapeutic applications.
Used in Anti-cancer Applications:
thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione is studied for its potential as an anti-cancer agent, where it may contribute to the development of novel treatments for various types of cancer. Its specific role in anti-cancer research is attributed to its ability to target and affect cellular processes that are crucial for tumor growth and progression.
Used in Anti-inflammatory Applications:
Thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione has also demonstrated anti-inflammatory properties, making it a candidate for use in treatments aimed at reducing inflammation and associated symptoms in various conditions.
Used in Antimicrobial Applications:
Furthermore, thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione has shown antimicrobial activity, suggesting its potential use in the development of new antibiotics or antifungal agents to combat resistant strains and treat infections.
As research continues, the diverse applications of thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione may expand, leading to its incorporation in multiple areas of medicine and healthcare.

InChI:InChI=1/C5H3N3O2S/c9-3-2-4(11-1-6-2)8-5(10)7-3/h1H,(H2,7,8,9,10)

Upstream product

• 5021-69-2 (4-carbamoylthiazol-5-yl)carbamic acid ethyl ester 
• 64-18-6 formic acid 
• 34771-17-0 5-amino-4-thio-barbituric acid 

Downstream Products

• 1542711-02-3 N-benzyl-5-chlorothiazolo[5,4-d]pyrimidin-7-amine 
• 13479-88-4 5,7-dichloro-[1,3]thiazolo[5,4-d]pyrimidine 
• 1542704-23-3 N-benzyl-5-(2-methoxy-1H-benzo[d]imidazol-1-yl)thiazolo[5,4-d]pyrimidin-7-amine 
• 1542711-03-4 C₁₈H₁₆N₆S 
• 35867-91-5 4-β-D-ribofuranosyl-4H-thiazolo[5,4-d]pyrimidine-5,7-dione 
• 55520-52-0 7-thioxo-4,6-bis-(tri-O-benzoyl-β-D-ribofuranosyl)-6,7-dihydro-4H-thiazolo[5,4-d]pyrimidin-5-one 
• 55520-48-4 7-methylsulfanyl-4-(tri-O-benzoyl-β-D-ribofuranosyl)-4H-thiazolo[5,4-d]pyrimidin-5-one 
• 55520-46-2 7-thioxo-4-(tri-O-benzoyl-β-D-ribofuranosyl)-6,7-dihydro-4H-thiazolo[5,4-d]pyrimidin-5-one 
• 55520-47-3 7-amino-4-β-D-ribofuranosyl-4H-thiazolo[5,4-d]pyrimidin-5-one 
• 55520-41-7 4-(tri-O-benzoyl-α-D-ribofuranosyl)-4H-thiazolo[5,4-d]pyrimidine-5,7-dione 
• 35867-92-6 4-(tri-O-benzoyl-β-D-ribofuranosyl)-4H-thiazolo[5,4-d]pyrimidine-5,7-dione 
• 55520-49-5 6-(tri-O-benzoyl-β-D-ribofuranosyl)-4H-thiazolo[5,4-d]pyrimidine-5,7-dione 

Relevant academic research and scientific papers

IRAK INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.

Convenient synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine

A convenient synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine is reported. The condensation of ethyl isocyanoacetate and ethoxycarbonyl isothiocyanate selectively gave the key 5-aminothiazole intermediate in high yield under mild conditions. This interm