134804-65-2

Upstream product

• 134804-64-1 1-(3',5'-dimethoxyphenyl)-2-(2-hydroxy-4,6-dimethoxyphenyl)-3,3-dimethoxypropan-1-one 
• 500-99-2 3,5-dimethoxyphenol 
• 50841-50-4 (2-bromo-1-(3,5-dimethoxyphenyl)ethanone) 
• 134804-61-8 1-(3',5'-dimethoxyphenyl)-2-(2-benzyloxy-4,6-dimethoxyphenyl)-3,3-dimethoxypropan-1-one 
• 134804-55-0 2-benzyloxy-3',4,5',6-tetramethoxychalcone 
• 54917-02-1 2-(benzyloxy)-4,6-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

Regioselective preparation of benzo[b]furans from Phenols and α-Bromoketones

In this paper, a fully regiocontrolled synthesis of either 2- and 3-substituted benzo[b]furans is described. Direct reaction between phenols and α-bromoacetophenones in the presence of neutral alumina yields 2-substituted benzo[b]furans with complete regiocontrol. When a basic salt such as potassium carbonate is used, the corresponding 2-oxoether is obtained. Cyclization of these latter compounds promoted by neutral alumina yields the corresponding 3-substituted benzo[b]furans. Using the former method, Moracin M and other analogues can be obtained from commercial sources in two preparative steps. DFT calculations provide reasonable reaction paths to understand the formation of 2-substituted benzo[b]furans.

Polysubstituted benzofurans and medicinal applications thereof

The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processe

Synthesis of 2-arylbenzofuran phytoalexins

A new synthesis of 2-arylbenzofuran using direct oxidative rearrangement of 2-benzyloxychalcones by Tl(ONO2)3 followed by cyclization of the key intermediates: 2-benzyloxypropan-1-ones is described.The method has been applied to the synthesis of six 2-ary