13481-84-0

Upstream product

• 644-62-2 MECLOFENAMIC ACID 
• 79-37-8 oxalyl dichloride 
• 13625-29-1 1,3-bis-(2,6-dichloro-3-methyl-phenyl)-1H-quinazoline-2,4-dione 
• 22121-56-8 meclofenamic acid chloride 

Downstream Products

• 133239-48-2 2-<(2,6-dichloro-3-methylphenyl)amino>benzenethioamide 
• 1618-57-1 2-[(2,6-dichloro-3-methylphenyl)amino]-benzene 
• 133239-42-6 2,6-dichloro-3-methyl-N-<2-<5-(methylsulfinyl)-1,3,4-thiadiazol-2-yl>phenyl>benzenamine 
• 133239-41-5 2,6-dichloro-3-methyl-N-<2-<5-(methylthio)-1,3,4-thiadiazol-2-yl>phenyl>benzenamine 
• 133239-17-5 5-<2-<(2,6-dichloro-3-methylphenyl)amino>phenyl>-1,3,4-thiadiazole-2(3H)-thione 
• 133239-49-3 2-<(2,6-dichloro-3-methylphenyl)amino>benzenecarboximidic acid hydrazide 
• 13481-74-8 2-(2,6-dichloro-3-methylanilino)benzonitrile 

Relevant academic research and scientific papers

FENAMATE 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS ANTIINFLAMMATORY AGENTS

The present invention is novel compounds which are 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, and pharamaceutically acceptable acid addition or base salts thereof having activity as inhibitors of singly or together 5-lipoxygenase and cyclooxygenase, and pharmaceutical compositions or methods of use therefor.

1,3,4-oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: In vitro inhibition of cyclooxygenase and 5-lipoxygenase activities

N-Arylanthranilic acids, known generically as the fenamates, are nonsteroidal antiinflammatory drugs (NSAIDs) that block the metabolism of arachidonic acid by the enzyme cyclooxygenase (CO). Substitution of the carboxylic acid functionality of several fen