13482-66-1

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 74-89-5 methylamine 
• 4114-31-2 ethylhydrazine carboxylate 
• 593-51-1 methylamine hydrochloride 
• 15429-42-2 2-(Ethoxycarbonyl)-1-hydrazincarbonylchlorid 
• 85210-15-7 1-ethyl 2-phenyl hydrazine-1,2-dicarboxylate 
• 13256-32-1 1,3 dimethyl 1 nitrosourea 
• 624-83-9 methyl isocyanate 

Downstream Products

• 16312-79-1 4-methylurazole 
• 13274-43-6 4-methyl-1,2,4-triazoline-3,5-dione 

Relevant academic research and scientific papers

Preparation of 2-(alkylcarbamoyl)hydrazine-1-carboxylic acid alkyl ester or its corresponding urazole salt

The present invention relates to the preparation of 2-(alkylcarbamoyl)hydrazine-1-carboxylic acid alkyl ester or its corresponding urazole salt. The present invention relates to 2-(alkylcarbamoyl)hydrazine-1-alkyl carboxylate or its corresponding derivative alkyl-4H-1,2,4-triazole-3,5-diol salt (urine Azole salt) preparation. This is particularly advantageous because it uses a one-pot reaction and uses alkyl acetate as the solvent in steps a) and b) of its synthesis.

Development of a Scalable and Sublimation-Free Route to MTAD

The cyclic azodicarbonyl 4-methyl-1,2,4-triazoline-3,5-dione (MTAD) is a versatile and powerful reagent used mainly in cycloaddition chemistry. Though known for more than 50 years, its unsafe preparation, as well as purification by sublimation, hampered i

METHOD FOR PRODUCING SEMICARBAZIDE COMPOUND, AND METHOD FOR PRODUCING TRIAZOLIDINEDIONE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for synthesizing a semicarbazide compound which gives the semicarbazide compound without passing through an acyl azide. SOLUTION: Carbonylating agents such as carbonyl diimidazole (CDI) and triphosgene (TCF) are brought into contact with either one of an amine compound and a carbazate compound to form an active intermediate. A semicarbazide compound is synthesized by reacting the resulting active intermediate with the remaining one of the amine compound and the carbazate compound. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Alternative synthetic routes to N-methyl-1,2,4-triazoline-3,5-dione (MeTAD) and other triazolinedione derivatives

N-Methyl-1,2,4-triazoline-3,5-dione (MeTAD) is a powerful electrophile and a versatile synthetic reagent. In this Letter we describe two methods for the synthesis of N-methylurazole, the direct precursor to MeTAD, on gram scales and in good yields. Both methods provide pure urazole while avoiding the necessity of large scale purification via column chromatography or recrystallization. One of the methods proved to be amenable for the synthesis of derivatives other than N-methyl.