13488-79-4

Upstream product

• 75-21-8 oxirane 
• 7127-19-7 2-phenyl-1,3-oxazoline 
• 100-47-0 benzonitrile 
• 111-42-2 2,2'-iminobis[ethanol] 
• 90238-20-3 N,N-diethyl-α,α-difluorobenzylamine 
• 4337-66-0 β-hydroxyethylammonium benzoate 
• 18838-10-3 N-(2-hydroxyethyl)-benzamide 

Relevant academic research and scientific papers

Facile synthesis of bicyclo orthoesters and bicyclo amide acetals using α,α-difluoroalkylamines

Bicyclo orthoesters and amide acetals were prepared from the corresponding triols or diethanolamines using α,α-difluoroalkylamines. The reaction proceeded under milder conditions than conventional methods. 4-tert-Butyl-1-(4-ethynylphenyl)trioxabicyclo[2.2.2]octane, a new class of insecticide, was prepared from a triol in three steps using a difluoroalkylamine.

Preparation and characterization of bicyclic amide acetals and monothioacetals

We have prepared and characterized new examples of 5-substituted-1-aza-4,6- dioxabicyclo[3.3.0]octanes (bicyclic amide acetals) and examples of the new heterocyclic system, 5-substituted-1-aza-4-oxa-6-thiabicyclo[3.3.0]octanes (bicyclic amide monothioacetals). Detailed analysis of NMR coupling constants and X-ray structure determination for an example of each class of compound established the stereochemistry and conformation of these ring systems.