134882-63-6

Usage

Uses

Used in Organic Synthesis:
4-Fluoro-2-Methyl-5-nitroanisole is utilized as an intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for further reactions and modifications, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Fluoro-2-Methyl-5-nitroanisole is employed as a key intermediate in the development of new drugs. Its presence in the molecular structure can influence the pharmacological properties of the final drug product, such as potency, selectivity, and bioavailability.
Used in Agrochemical Production:
4-Fluoro-2-Methyl-5-nitroanisole also has potential applications in the agrochemical sector. It can be used as a building block in the synthesis of various agrochemicals, such as pesticides and herbicides, to improve their effectiveness and selectivity in controlling pests and weeds.
Safety Considerations:
It is crucial to handle 4-Fluoro-2-Methyl-5-nitroanisole with care, as it may pose risks to human health and the environment if not properly managed. Adequate safety measures, such as wearing protective gear and working in well-ventilated areas, should be taken to minimize exposure and potential hazards.

Upstream product

• 452-72-2 4-fluoro-2-methylphenol 
• 123401-18-3 carbonic acid 4-fluoro-2-methyl-5-nitro-phenyl ester methyl ester 
• 122455-86-1 (4-fluoro-2-methylphenyl)methylcarbonate 
• 122455-84-9 2-methyl-4-fluoro-5-nitrophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 678969-87-4 acetic acid acetoxy-(5-fluoro-2-methoxy-4-nitro-phenyl)-methyl ester 
• 932374-47-5 1,1-dimethylethyl 4-{[5-methyl-4-methoxy-2-nitrophenyl]amino}-1-piperidinecarboxylate 
• 1262898-01-0 4-(3,3-dimethylbutyrylamino)-5-fluoro-2-methoxybenzoic acid 
• 1262897-93-7 N-(2-fluoro-5-methoxy-4-methylphenyl)-3,3-dimethylbutyramide 
• 1262897-90-4 4-(3,3-dimethylbutyrylamino)-5-fluoro-2-methoxy-N-thiazol-2-ylbenzamide 
• 1232505-74-6 2-fluoro-5-methoxy-4-methylphenylamine 
• 1071973-93-7 cyano-(4-methoxy-5-methyl-2-nitrophenyl)acetic acid methyl ester 
• 678969-89-6 5-(5-fluoro-2-methoxy-4-nitrophenyl)oxazole 
• 678969-88-5 5-fluoro-2-methoxy-4-nitrobenzaldehyde 

Relevant academic research and scientific papers

Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)- 3,5-difluorobenzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A phosphonooxymethylene prodrug of a potent and selective hA2A receptor antagonist

The discovery and structure-activity relationship of a series of hA 2A receptor antagonists is described. Compound 28 was selected from the series as a potent and selective compound and was shown to be efficacious in an in vivo model of Parkinson's disease. It had acceptableADME properties; however, the low intrinsic solubility of this compound was limiting for its developability, because the oral bioavailability from dosing in suspension was significantly lower than the oral bioavailability from solution dosage. As a consequence, prodrugs of 28 were prepared with dramatically increased aqueous solubility. The prodrugs efficiently delivered 28 into systemic circulation, with no detectable levels of prodrug in plasma samples. From this investigation, we selected 32 (Lu AA47070), a phosphonooxymethylene prodrug of 28, as a drug candidate.

DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

DIHYDROPYRIDONE AMIDESAS P2X7 MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

(AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, -N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) and salts and solvates are provided: In a first aspect therefore, the invention provides a compound of formula (I) or a salt or solvate thereof: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C 1-6 alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-methoxy-4-(5-oxazolyl)phenyl moiety

The first reported structure-activity relationships (SARs) about the N-[3-methoxy-4-(5-oxazolyl)phenyl moiety for a series of recently disclosed inosine monophosphate dehydrogenase (IMPDH) inhibitors are described. The syntheses and in vitro inhibitory values for IMPDH II, and T-cell proliferation (for select analogues) are given.