Welcome to LookChem.com Sign In|Join Free


  • or


Post Buying Request

452-72-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

452-72-2 Usage


4-Fluoro-2-methylphenol is an organic compound characterized by the presence of a fluorine atom at the 4-position and a methyl group at the 2-position on a phenol ring. It is known for its unique chemical properties and reactivity, making it a versatile building block in various chemical processes.


Used in Organic Synthesis:
4-Fluoro-2-methylphenol is used as a key intermediate for the synthesis of various organic compounds. Its unique structure allows for selective reactions and functional group transformations, facilitating the production of a wide range of chemical products.
Used in Pharmaceutical Industry:
4-Fluoro-2-methylphenol is utilized as a building block in the development of pharmaceuticals. Its presence in drug molecules can impart specific biological activities and properties, such as improved pharmacokinetics, enhanced potency, or targeted delivery.
Used in Agrochemicals:
In the agrochemical industry, 4-Fluoro-2-methylphenol is employed as a starting material for the synthesis of various agrochemical products. Its incorporation into these compounds can lead to improved efficacy, selectivity, or environmental compatibility.
Used in Dye Industry:
4-Fluoro-2-methylphenol is used as a raw material in the production of dyes. Its unique structure contributes to the color and properties of the resulting dyes, allowing for the creation of a diverse range of colorants for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 452-72-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 452-72:
62 % 10 = 2
So 452-72-2 is a valid CAS Registry Number.

452-72-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A16032)  4-Fluoro-2-methylphenol, 98%   

  • 452-72-2

  • 5g

  • 342.0CNY

  • Detail
  • Alfa Aesar

  • (A16032)  4-Fluoro-2-methylphenol, 98%   

  • 452-72-2

  • 25g

  • 1342.0CNY

  • Detail
  • Alfa Aesar

  • (A16032)  4-Fluoro-2-methylphenol, 98%   

  • 452-72-2

  • 100g

  • 4278.0CNY

  • Detail

452-72-2Relevant articles and documents

Preparation method of 2-bromo-4-fluoro-6-methylphenol


Paragraph 0027-0029; 0032-0035, (2020/11/09)

The invention discloses a preparation method of 2-bromo-4-fluoro-6-methylphenol, and belongs to the technical field of fine chemical engineering. The preparation method of 2-bromo-4-fluoro-6-methylphenol comprises the following steps of: (1) diazotization hydrolysis reaction: carrying out diazotization hydrolysis reaction on 2-methyl-4-fluoroaniline to obtain 2-methyl-4-fluorophenol; and (2) bromination reaction: carrying out bromination reaction on the 2-methyl-4-fluorophenol prepared in the step (1) to prepare the 2-bromo-4-fluoro-6-methylphenol. According to the method, nitrosyl sulfuric acid is adopted as an acylation reagent, waste acid obtained after diazotization hydrolysis is completed does not contain salt, acidic wastewater is easy to treat, and industrial production is facilitated; bromine used in the bromination reaction is greatly reduced, and the technological process is more environmentally friendly.

Catalytic activation of unstrained C(aryl)–C(aryl) bonds in 2,2′-biphenols

Zhu, Jun,Wang, Jianchun,Dong, Guangbin

, p. 45 - 51 (2018/11/23)

Transition metal catalysis has emerged as an important means for C–C activation that allows mild and selective transformations. However, the current scope of C–C bonds that can be activated is primarily restricted to either highly strained systems or more polarized C–C bonds. In contrast, the catalytic activation of non-polar and unstrained C–C moieties remains an unmet challenge. Here we report a general approach for the catalytic activation of the unstrained C(aryl)–C(aryl) bonds in 2,2′-biphenols. The key is to utilize the phenol moiety as a handle to install phosphinites as a recyclable directing group. Using hydrogen gas as the reductant, monophenols are obtained with a low catalyst loading and high functional group tolerance. This approach is also applied to the synthesis of 2,3,4-trisubstituted phenols. A further mechanistic study suggests that the C–C activation step is mediated by a rhodium(i) monohydride species. Finally, a preliminary study on breaking the inert biphenolic moieties in lignin models is illustrated.

A novel improvement in ArLPdF catalytic fluorination of aromatic compounds

Samant, Bhupesh S.,Bhagwat, Sunil S.

experimental part, p. 191 - 194 (2012/01/05)

In this study, we used reverse micellar medium for overcoming the disadvantages of ArLMF catalytic fluorination of aromatic compounds. It not only enhanced the fluorination rate, but also widened the scope of reaction for bromoaromatics with electron donating and withdrawing functionalities at ortho position. Various bromoaromatic compounds were fluorinated using the biarylphosphine ligand i.e. cyclohexyl BrettPhos ligand, along with [cinnamylPdCl]2, and CsF as the fluoride source in reverse micellar media. The anisotropic palisade layer of reverse micelles provided the active site for reaction. The most crucial factor in the critical reductive elimination step could be the spatial orientation of ArLPdF complex in the palisade layer; forming ArF as the final product in high yield with excellent selectivity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 452-72-2