1349155-42-5Relevant articles and documents
Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies
Wang, Haofan,Byun, Youngjoo,Barinka, Cyril,Pullambhatla, Mrudula,Bhang, Hyo-eun C.,Fox, James J.,Lubkowski, Jacek,Mease, Ronnie C.,Pomper, Martin G.
supporting information; experimental part, p. 392 - 397 (2010/04/02)
We report a strategy based on bioisosterism to improve the physicochemical properties of existing hydrophilic, urea-based GCPII inhibitors. Comprehensive structure-activity relationship studies of the P1′ site of ZJ-43- and DCIBzL-based compounds identifi