39028-25-6Relevant articles and documents
Copper-mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide
Kondo, Yuto,Kimura, Hiroyuki,Fukumoto, Chiaki,Yagi, Yusuke,Hattori, Yasunao,Kawashima, Hidekazu,Yasui, Hiroyuki
, p. 336 - 345 (2021/05/27)
A copper-mediated radioiodination using aryl boronic precursors is attracting attention as a solution to oxidative iododestannylation and nickel-mediated radioiodination drawbacks. The copper-mediated radiolabeling method allows radioiodination at room te
Synthesis and evaluation of novel radioiodinated PSMA targeting ligands for potential radiotherapy of prostate cancer
Alexoff, David,Choi, Seok Rye,Kung, Hank F.,Ploessl, Karl,Yao, Xinyue,Zha, Zhihao,Zhao, Ruiyue,Zhu, Lin
, (2020/01/31)
Radioligand therapy (RLT) using prostate-specific membrane antigen (PSMA) targeting ligands is an attractive option for the treatment of Prostate cancer (PCa) and its metastases. We report herein a series of radioiodinated glutamate-urea-lysine-phenylalan
Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature
Reilly, Sean W.,Makvandi, Mehran,Xu, Kuiying,Mach, Robert H.
supporting information, p. 1752 - 1755 (2018/04/14)
Access to 211At- and 125I-radiolabeled compounds in excellent RCCs and RCYs was achieved in just 10 min at room temperature using a Cu catalyst. The reaction conditions are applicable to a broad class of aryl and heteroaryl boronic reagents with varying steric and electronic properties as well as late-stage astatination and iodination of anticancer PARP inhibitors. This protocol eliminates the traditional need for toxic organotin reagents, elevated temperatures, and extended reaction times, providing a more practical and environmentally friendly approach to developing α-emitting radiotherapeutics.