134919-53-2Relevant academic research and scientific papers
Some Diastereoselective Enzyme-catalysed Esterifications and Interesterifications
Macfarlane, Emma L. A.,Roberts, Stanley M.,Steukers, Veronique G. R.,Taylor, Philip L.
, p. 2287 - 2290 (2007/10/02)
The alcohol bicycloheptenol (+/-)-1 or the corresponding acetate (+/-)-5 couple with 2-(p-chlorophenoxy)propionic acid (+/-)-2 using lipases in organic solvents to give the ester bicycloheptenyl 2-(p-chlorophenyl)propionate (R,R)-3 with good/excellent selectivity.Similarly, 2-methoxycyclohexanol (+/-)-6 or the corresponding acetate (+/-)-7 undergo enzyme-induced coupling to the acid (+/-)-2 to form the (R,R,R)-ester 2-methoxycyclohexyl p-chlorophenoxyacetate 8 almost exclusively in a doubly enantioselective process.
Highly Diastereoselective Inter-esterification Reactions Involving a Racemic Acetate and a Racemic Carboxylic Acid catalysed by Lipase Enzymes
Fowler, Patrick W.,Macfarlane, Emma L. A.,Roberts, Stanley M.
, p. 453 - 455 (2007/10/02)
Reaction of the acetate (+/-)-8 with the acid (+/-)-2 using Candida cylindracea lipase or Lipase AY as catalyst gave mainly the (R,R)-diastereoisomer 4 (91 +/-0.5percent) with minimal amounts of the other diastereoisomers 3,5 and 6 (5.5percent).
