3307-39-9

Usage

Uses

2-(4-Chlorophenoxy) propionic acid

Purification Methods

Crystallise pKEst the acid from EtOH or HCOOH (m 114.5-115.5o). It is a plant growth substance. The R(+)-and S(-)-enantomers have m 103-104o (from pet ether) and [] 25 ±41o (c 1, EtOH). [Beilstein 6 III 695, 6 IV 850.]

InChI:InChI=1/C9H9ClO3/c1-6(9(11)12)13-8-4-2-7(10)3-5-8/h2-6H,1H3,(H,11,12)/p-1/t6-/m1/s1

Upstream product

• 940-31-8 2-phenoxypropionic acid 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 64-19-7 acetic acid 
• 95262-84-3 2-(4-chlorophenoxy)propanoic acid methyl ester 
• 1193-00-6 sodium 4-chlorophenolate 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 106-48-9 4-chloro-phenol 
• 357-57-3 brucine 
• 156-34-3 l-amphetamine 
• 133707-34-3 2-(4-Chloro-phenoxy)-propionic acid isopropyl ester 
• 535-11-5 Ethyl 2-bromopropionate 
• 4878-20-0 2-(4-Chlorophenoxy)propionic acid chloride 
• 18671-89-1 cyclopropyl 4-(2-chlorophenoxy)butanoate 
• 316141-72-7 (R,S)-2-(4-chlorophenoxy)propionyl 1,2,4-triazolide 

Downstream Products

• 3307-39-9 (R)-2-(4-chlorophenoxy)propanoic acid 
• 3307-39-9 (S)-2-(4-chlorophenoxy)propionic acid 
• 15485-48-0 2-<4-Chlorphenoxy>-propionsaeure-<2-dimethylaminoethylester> 
• 65569-34-8 5-Chloro-4-[2-(4-chloro-phenoxy)-propionylamino]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide 
• 63650-24-8 2-(4-chlorophenoxy)-1-propanol 
• 106690-22-6 3-Benzo[1,3]dioxol-5-yl-6-[1-(4-chloro-phenoxy)-ethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 95262-84-3 2-(4-chlorophenoxy)propanoic acid methyl ester 
• 99210-92-1 (R)-2-(4-chlorophenoxy)propanoic acid methyl ester 
• 95342-42-0 (S)-2-(4-chlorophenoxy)propionic acid methyl ester 
• 135092-51-2 (S)-2-(4-Chloro-phenoxy)-propionic acid (1S,5R,6S)-bicyclo[3.2.0]hept-2-en-6-yl ester 
• 135092-52-3 (R)-2-(4-Chloro-phenoxy)-propionic acid (1S,5R,6S)-bicyclo[3.2.0]hept-2-en-6-yl ester 
• 134919-53-2 (S)-2-(4-Chloro-phenoxy)-propionic acid (1R,5S,6R)-bicyclo[3.2.0]hept-2-en-6-yl ester 
• 135092-50-1 (R)-2-(4-Chloro-phenoxy)-propionic acid (1R,5S,6R)-bicyclo[3.2.0]hept-2-en-6-yl ester 
• 4878-20-0 2-(4-Chlorophenoxy)propionic acid chloride 

Relevant academic research and scientific papers

Preparation method of (R)-(+)-2-(4-hydroxyphenoxy) propionic acid

The invention provides a preparation method of (R)-(+)-2-(4-hydroxyphenoxy) propionic acid, and belongs to the technical field of pesticide intermediates. Phenol compounds (parachlorophenol, p-bromophenol, p-iodophenol or p-hydroxybenzenesulfonic acid) are adopted as raw materials and react with (S)-(-)-2-chloropropionic acid to synthesize R-(+)-2-(4-chlorophenoxy) propionic acid, and the (R)-(+)-2-(4-hydroxyphenoxy) propionic acid is obtained after hydrogen hydrolysis. The raw material phenol compound used in the invention is low in price and simple in process operation; and the method avoids using hydroquinone as a raw material, and solves the problems of high raw material cost, difficult product purification and low product quality caused by hydroquinone disubstituted impurities generated in the reaction when hydroquinone is used as a raw material for synthesis in the traditional method.

Anti-hepatic fibrosis compound, preparation, preparation method and application

The invention belongs to the technical field of medicines, in particular to an anti-hepatic fibrosis compound, a preparation, a preparation method and application, and the structural formula of the anti-hepatic fibrosis compound is shown in the specification. The anti-hepatic fibrosis compound can obviously improve hepatic fibrosis, improve liver function indexes, reduce extracellular matrix accumulation of collagen and the like in extracellular interstitial substances, reduce the degree of hepatic fibrosis and inhibit the formation and development of hepatic fibrosis.

Access to Optically Enriched α-Aryloxycarboxylic Esters via Carbene-Catalyzed Dynamic Kinetic Resolution and Transesterification

Optically active α-aryloxycarboxylic acids and their derivatives are important functional molecules. Disclosed here is a carbene-catalyzed dynamic kinetic resolution and transesterification reaction for access to this class of molecules with up to 99% yields and 99:1 er values. Addition of a chiral carbene catalyst to the ester substrate leads to two diastereomeric azolium ester intermediates that can quickly epimerize to each other and thus allows for effective dynamic kinetic resolution to be realized. The optically enriched ester products from our reaction can be quickly transformed to chiral herbicides and other bioactive molecules.

Synthesis method of(R)-2-[4-(4-cyano-2-fluorophenoxy)phenoxy] propionic acid

The invention discloses a method for synthesizing cyhalofop butyl intermediate(R)-2-[4-(4-cyano-2-fluorophenoxy)phenoxy] propionic acid.(S)-2-chloropropionic acid methyl ester and p-chlorophenol are used as raw materials, an etherification reaction is performed under an alkaline condition to generate(R)-2-(4-hydroxyphenoxy)propionic acid, and the etherification product and 3-fluoro-4-hydroxybenzonitrile generate the(R)-2-[4-(4-cyano-2-fluorophenoxy)phenoxy] propionic acid under the action of an acid-binding agent. According to the method, the problems of serious excessive hydroquinone servingas a raw material, massive use of an inorganic base and generation of dietherification byproducts in synthesis are avoided. The method is high in atom utilization rate, high in reaction yield and lowin production cost.

Anti-hepatic fibrosis compound and preparation as well as preparation method and application of compound

The invention belongs to the technical field of medicines, and in particular relates to an anti-hepatic fibrosis compound and a preparation as well as a preparation method and application of the compound. A structural formula of the anti-hepatic fibrosis compound is shown in the specification. The anti-hepatic fibrosis compound can obviously improve hepatic fibrosis, improve liver function indexes, reduce accumulation of extracellular matrixes such as collagen in extracellular interstitial substances, reduce the degree of the hepatic fibrosis and inhibit the formation and development of the hepatic fibrosis.

Compounds For The Treatment Of Neuromuscular Disorders

The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the ClC-1 ion channel. The compounds include phenoxy propanoic acid, phenoxy propanoate, and phenoxy butanoate compounds.

Preparation method of phenoxycarboxylic acid herbicide

The invention provides a preparation method of a phenoxycarboxylic acid herbicide, wherein the preparation method includes the steps: S1, carrying out condensation reaction of phenol or o-cresol withchlorocarboxylic ester under the action of an alkaline substance to obtain phenoxycarboxylic ester, wherein the chlorocarboxylic ester has the general formula of ClR1COOR, R1 is C1-3 alkylene or alkylidene, and R is C1-10 alkyl or C3-10 cycloalkyl; S2, carrying out selective chlorination of phenoxycarboxylic ester with a chlorinating agent under the action of a first catalyst and a second catalyst, to obtain chlorobenzoxycarboxylic ester, wherein the first catalyst is selected from Lewis acid, the second catalyst is C5-22 thioether compounds, thiazole compounds, isothiazole compounds or thiophene compounds; and S3, carrying out acidolysis reaction of chlorobenzoxycarboxylic ester, to obtain the phenoxycarboxylic acid herbicide represented by the formula I, wherein R3 is H, Cl or CH3. The preparation method can improve the product quality and the operation environment of a production site, and has low quantity of three wastes.

A method for preparing chloro-benzene oxygen carboxylic acid (by machine translation)

The invention provides a method for preparing carboxylic acid chloro-benzene oxygen, comprising the following steps: S1) phenoxy fatty alcohol in the catalyst B A and under the action of the catalyst, and the chlorinating agent to 2 bit and/or 4 bit selective chlorination reaction, to obtain chloro-benzene oxygen fatty alcohol; said catalyst A is Lewis acid; said catalyst B is C5 - 22 of the thioether, thiazole, isothiazole, thiophene or their halogenated derivatives; S2) [...] fatty alcohol and water, under the action of a catalyst, and an oxidizing agent for the selective catalytic oxidation reaction, get chloro-benzene oxygen carboxylic acid. The invention through the re-design of the process route, the catalyst and the chlorinating agent fine screening, effectively reduces the energy consumption, the selectivity of the dichloride to improve at the same time avoiding the losses of the active ingredient, the resulting chloro-benzene oxygen carboxylic acid content can be up to 98.5% or more, the total yield can be up to 99% or more. (by machine translation)

A phenoxy carboxylic acid herbicide preparation method (by machine translation)

The invention provides a phenoxy carboxylic acid herbicide preparation method, including: S1, will be [...], alkaline substance mixed with the chlorinated carboxylic acid ester, in the one-pot condensation reaction in anhydrous system, phenoxy carboxylic acid ester obtained; the ClR states the chloro- carboxylic acid ester of the formula is1 COOR, R1 Is C1 - 3 alkylene or alkylidene, R is C1 - 10 alkyl or C3 - 10 cycloalkyl; S2, the [...] ester in the 1st and 2nd catalyst under the action of a catalyst, with the chlorinating agent to carry out the selective chlorination of, get [...] ester; the Lewis acid catalyst is selected from 1st, 2nd catalyst is C5 - 22 of the thioether compound, thiazole compound, isothiazole compound or thiophene compound; S3, will the [...] ester to acid hydrolysis reaction, as shown in formula I phenoxy carboxylic acid herbicide, R3 Is H, Cl or CH3 . This invention can improve the quality of the products and the operating environment of production, three waste low. (by machine translation)

Preparation method of phenoxycarboxylic acid herbicide

The invention provides a preparation method of a phenoxycarboxylic acid herbicide, wherein the preparation method includes the steps: S1, carrying out reaction of anhydrous phenol with an active metalto form phenoxide, and carrying out condensation reaction of the phenoxide with chlorocarboxylic ester to obtain phenoxycarboxylic ester, wherein the chlorocarboxylic ester has the general formula ofClR1COOR, R1 is C1-3 alkylene or alkylidene, and R is C1-10 alkyl or C3-10 of cycloalkyl; S2, carrying out selective chlorination of the phenoxycarboxylic ester with a chlorinating agent in the presence of a first catalyst and a second catalyst to obtain chlorobenzoxycarboxylic ester, wherein the first catalyst is selected from Lewis acid, and the second catalyst is C5-22 thioether, thiazole, isothiazole or thiophene compounds; and S3, carrying out acidolysis reaction of chlorobenzoxycarboxylic ester to obtain the phenoxycarboxylic acid herbicide represented by the formula I, wherein R3 is H,Cl or CH3. The preparation method can improve the product quality and the operation environment of the production site, and has low quantity of three wastes.