134931-84-3

Upstream product

• 868-72-4 dimethyl 2,5-dibromohexanedioate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 868-72-4 dimethyl (2R,5S)-2,5-dibromohexanedioate 
• 868-72-4 dimethyl rac-2,5-dibromohexanedioate 
• 67-56-1 methanol 
• 134860-28-9 1-<(S)-1-Phenylethyl>-2,5-cis-bis(carboxy)pyrrolidine 

Downstream Products

• 148905-19-5 (2R,5R)-1-((S)-1-Phenylethyl)-2,5-bis(methoxymethoxymethyl)pyrrolidine 
• 148773-70-0 (2S,5S)-1-<(S)-1-Phenylethyl>-2,5-bis(methoxymethoxymethyl)pyrrolidine 
• 148812-16-2 (2R,5R)-1-((S)-1-Phenylethyl)-2,5-bis(hydroxymethyl)pyrrolidine 
• 148773-68-6 (2S,5S)-1-<(S)-1-Phenylethyl>-2,5-bis(hydroxymethyl)pyrrolidine 
• 93713-35-0 (2R,5R)-2,5-Pyrrolidinedicarboxylic acid 
• 81702-31-0 (2S,5S)-pyrrolidine-2,5-dicarboxylic acid 
• 134860-27-8 1-<(S)-1-Phenylethyl>-2,5-(R,R)-bis(methoxycarbonyl)pyrrolidine 
• 134860-26-7 1-<(S)-1-Phenylethyl>-2,5-(S,S)-bis(methoxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis of new, highly hindered C2-symmetric trans-(2S,5S)-disubstituted pyrrolidines

trans-(2S,5S)-(1,1-Diphenylmethyl)pyrrolidine has been prepared from the corresponding diester in four steps and 54% overall yield. Key steps involve the nucleophilic addition of an organomagnesiun reagent to a carbonyl compound promoted by cerium(III) ch

A convenient synthesis of enantiomeric pairs of 2,5-disubstituted pyrrolidines of C2-symmetry

By the use of (-)-1-phenylethylamine as a chiral auxiliary, three diastereomeric isomers of 2,5-bis(methoxycarbonyl)pyrrolidine derivatives are prepared from dimethyl rac-2,5-dibromadipate and separted by crystallization and chromatographic fractionation