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Asymmetric syntheses of 3-substituted-cyclohexanone derivatives by stereoselective conjugate addition to chiral 2-substituted-2-cyclohexen-1-ones
Schultz, Arthur G.,Harrington, Roger E.
, p. 4926 - 4931 (2007/10/02)
Chiral 2-substituted-2-cyclohexen-1-one 2a is prepared from 1a by Birch reduction followed by acid-catalyzed hydrolysis-olefin migration. Conjugate additions of organometallic reagents to 2a occur with good to excellent diastereoselectivities (Table I). E
