134936-46-2Relevant academic research and scientific papers
Stereoselective synthesis of trans-4,5-substituted 1,4,5,6-tetrahydropyridine-2-(olates)thiolates
Shestopalov,Litvinov,Rodinovskaya,Sharanin Yu.
, p. 402 - 404 (2007/10/02)
trans-4,5-Substituted 1,4,5,6-tetrahydropyridine-2-(olates)thiolates are prepared either from pyridinium salts and cyanoacetic acid derivatives or from pyridinium salts, aromatic aldehydes and ethyl cyanoacetate or cyanoacetamide in the presence of a base
STEREOSELECTIVE TRANSFORMATION OF 1,3-DITHIA-4-CYCLOHEXENE ENAMINONITRILES INTO SUBSTITUTED 3,4-trans-1,2,3,4-TETRAHYDROPYRIDINE-6-THIOLATES WITH PYRIDINIUM YLIDES
Shestopalov, A. M.,Demerkov, A. S.,Sharanin, Yu. A.,Litvinov, V. P.
, p. 867 - 871 (2007/10/02)
4-Amino-6-aryl-2,2-dialkyl-5-cyano-1,3-dithia-4-cyclohexenes react with pyridinium ylides in thermodynamically controlled conditions with the formation of 4-aryl-2-oxo-(thioxo)-3-(1-pyridino)-5-cyano-3,4-trans-1,2,3,4-tetrahydropyridine-6-thiolates.Arylidenecyanothioacetamides act as intermediates of this recyclization, and the corresponding pyridine-6-thiolates were obtained from them by an independent method.The synthesized hydrogenated pyridine-6-thiolates are in the half-chair conformation with a trans-diaxal position of the 3-H and 4-H hydrogen atoms.
