13494-44-5

Upstream product

• 5468-37-1 2-aminoacetophenone hydrochloride 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 32787-60-3 2-(2-nitrophenyl)-5-phenyloxazole 
• 1148122-17-1 2-(2'-nitrophenyl)-4-phenylthiazole 

Relevant academic research and scientific papers

AMIDE DERIVATIVES AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.