134955-33-2Relevant academic research and scientific papers
Synthesis and evaluation of 2′,4′,6′-trihydroxychalcones as a new class of tyrosinase inhibitors
Jun, Nishida,Hong, Gao,Jun, Kawabata
, p. 2396 - 2402 (2007)
In this study, we synthesized a series of hydroxychalcones and examined their tyrosinase inhibitory activity. The results showed that 2′,4′,6′-trihydroxychalcone (1), 2,2′,3,4′,6′-pentahydroxychalcone (4), 2′,3,4,4′,5,6′-hexahydroxychalcone (5), 2′,4′,6′-trihydroxy- 3,4-dimethoxychalcone (9) and 2,2′,4,4′,6′-pentahydroxychalcone (15) exhibited high inhibitory effects on tyrosinase with respect to l-tyrosine as a substrate. By the structure-activity relationship study, it was suggested that the 2′,4′,6′-trihydroxyl substructure in the chalcone skeleton were efficacious for the inhibition of tyrosinase activity. And also, the catechol structure on B-ring of chalcones was not advantageous for the inhibitory potency. Furthermore, 15 (IC50 = 1 μM) was found to show the highest activity out of a set of 15 hydroxychalcones, even better than both 2,2′,4,4′-tetrahydroxychalcone (13, IC50 = 5 μM) and kojic acid (16, IC50 = 12 μM), which were known as potent tyrosinase inhibitors. Kinetic study revealed that 15 acts as a competitive inhibitor of tyrosinase with Ki value of 3.1 μM.
REVISED STRUCTURES OF ALBANINS D AND E, GERANYLATED FLAVONES FROM MORUS ALBA
Fukai, Toshio,Nomura, Taro
, p. 499 - 510 (2007/10/02)
The chemical shifts of the proton signals of the hydrogen-bonded hydroxyl groups of albanins D and E, isolated from Morus alba L. (Moraceae), were compared with those of the hydroxyl groups of 6- or 8-isoprenoid substituted flavones to doubt the location
