134955-46-7

Upstream product

• 134955-30-9 4',5,7-tris(methoxymethyloxy)flavanone 
• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 
• 107-30-2 chloromethyl methyl ether 
• 134955-29-6 2′,4,4′-trimethoxymethoxy-6′-hydroxychalcone 
• 13057-17-5 bromethyl methyl ether 

Downstream Products

• 134955-37-6 7,4'-dimethoxymethyl-6-geranylapigenin 
• 134955-32-1 7,4'-dimethoxymethyl-5-O-geranylapigenin 
• 134955-39-8 7,4'-dimethoxymethyl-8-geranylapigenin 

Relevant academic research and scientific papers

Potent, selective, allosteric inhibition of human plasmin by sulfa non-saccharide glycosaminoglycan mimetics

Although plasmin inhibitors could be used in multiple disorders, their use has been restricted to preventing blood loss in hemostatic dysregulation because of poor efficacy and adverse effects of current agents. We reasoned that a new class of direct inhi

Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin

Three series of apigenin derivatives have been prepared by coupling the carboxyl alkyl group to 4′-, 5- or 7-hydroxyl groups of apigenin respectively. Preliminary biological evaluation in vitro revealed that xanthine oxidase inhibitory activity was improv

Novel [alpha]-glucosidase inhibitor

The invention provides a novel apigenin derivative or a pharmaceutically acceptable salt thereof for selectively inhibiting [alpha]-glucosidase. The derivative is represented as the formula I, wherein R1 and R2 are independently H or -(CH2)nCOOR3; R3 is H

Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: An SAR study

A library of 42 natural and synthetic flavonoids has been screened for their effect on cell proliferation and apoptosis in a human colonic cell line (HT-29). Examples of different classes of flavonoids have been screened, and the effects of hydroxylation, methoxylation and/or C-alkylation at various positions in the A- and B-rings have been assessed. Flavones and flavonols possess greater antiproliferative activity than chalcones and flavanones. With respect to structural modification of flavonoids, C-isoprenylation was by far the most effective, with substitution at the 8-position and longer chains, such as geranyl giving the best results. Finally, most compounds that significantly reduced cell survival also increased caspase activity, suggesting that at least part of their antiproliferative activity might be attributable to an apoptotic response.

REVISED STRUCTURES OF ALBANINS D AND E, GERANYLATED FLAVONES FROM MORUS ALBA

The chemical shifts of the proton signals of the hydrogen-bonded hydroxyl groups of albanins D and E, isolated from Morus alba L. (Moraceae), were compared with those of the hydroxyl groups of 6- or 8-isoprenoid substituted flavones to doubt the location