Potent, selective, allosteric inhibition of human plasmin by sulfa non-saccharide glycosaminoglycan mimetics

Article abstract of DOI:10.1021/acs.jmedchem.6b01474

Although plasmin inhibitors could be used in multiple disorders, their use has been restricted to preventing blood loss in hemostatic dysregulation because of poor efficacy and adverse effects of current agents. We reasoned that a new class of direct inhi