1349644-17-2

Basic information

• Product Name: Methyl 1-Boc-3-allylpiperidine-3-carboxylate
• Synonyms: Methyl 1-Boc-3-allylpiperidine-3-carboxylate;1-tert-butyl 3-methyl 3-(prop-2-en-1-yl)piperidine-1,3-dicarboxylate;1-tert-Butyl 3-methyl 3-allylpiperidine-1,3-dicarboxylate
• CAS NO: 1349644-17-2
• Molecular Formula: C15H25NO4
• Molecular Weight: 283.3633
• Mol File: 1349644-17-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 1-Boc-3-allylpiperidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-Boc-3-allylpiperidine-3-carboxylate(1349644-17-2)
• EPA Substance Registry System: Methyl 1-Boc-3-allylpiperidine-3-carboxylate(1349644-17-2)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 1349644-17-2(Hazardous Substances Data)

Usage

General Description

Methyl 1-Boc-3-allylpiperidine-3-carboxylate is a chemical compound with a molecular formula of C15H27NO3. It is a derivative of piperidine and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. The compound is a white solid with a molecular weight of 253.38 g/mol. Its main use is as a building block for the creation of various drugs and agrochemicals due to its versatility and reactivity. However, it is important to handle this chemical with care, as it can be hazardous if not properly managed.

Upstream product

• 106-95-6 allyl bromide 
• 148763-41-1 1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 

Downstream Products

• 374795-33-2 (RS)-1,1-dimethylethyl 2-oxa-1-oxo-7-azaspiro[4,5]decan-7-carboxylate 
• 1349643-97-5 7-{[4-(trifluoromethyl)phenyl]sulfonyl}-2-oxa-7-azaspiro[4.5]decan-1-one 
• 1349643-99-7 7-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2-oxa-7-azaspiro[4.5]decan-1-one 

Relevant articles and documents

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Synthesis and structure-activity relationship of a novel sulfone series of TNF-α converting enzyme inhibitors

Replacement of the amide functionality in IM491 (N-hydroxy-(5S,6S)-1- methyl-6-{[4-(2-methyl-4-quinolinylmethoxy)anilinyl]carbonyl} -5-piperidinecarboxamide) with a sulfonyl group led to a new series of α,β-cyclic and β,β-cyclic γ-sulfonyl hydroxamic acids, which were potent TNF-α converting enzyme (TACE) inhibitors. Among them, inhibitor 4b (N-hydroxy-(4S,5S)-1-methyl-5-{[4-(2-methyl-4- quinolinylmethoxy)phenyl]sulfonylmethyl}-4-pyrrolidinecarboxamide) exhibited IC50 values of 1 nM and 180 nM in porcine TACE (pTACE) and cell assays, respectively, with excellent selectivity over MMP-1, -2, -9 and -13 and was orally bioavailable with an F value of 46% in mice.