1349698-22-1

Upstream product

• 73290-22-9 2-bromo-5-iodo-pyridine 
• 937183-61-4 4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene 
• 1289627-61-7 tert-butyl N-[4-(2-iodoethyl)phenyl]carbamate 
• 193204-58-9 tert-butyl N-(4-{2-[(4-methylbenzenesulfonyl)oxy]ethyl}phenyl)carbamate 

Downstream Products

• 1234208-02-6 (E)-tert-butyl N-(4-(2-(6-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl)-N-methylcarbamate 
• 1349697-99-9 4-[(E)-2-(6-⁽¹⁸⁾fluoropyridin-3-yl)vinyl]-N-methylaniline 

Relevant academic research and scientific papers

Synthetic method AV - 45 intermediate (by machine translation)

The synthesis method of AV - 45 intermediate comprises the following steps: Step (1): The reaction of tert-butyl - N N-methyl -4 - vinylphenyl carbamate and 2 - bromo -5 - iodopyridine to obtain the intermediate A; step (2): condensation of the intermediate A and triethylene glycol to obtain a target compound. The synthesis method of the (E)-tert-butyl -4 - (2 - (6 - (2 - (2 -hydroxyethoxy) ethoxy) pyridin 2 -3 -yl) phenyl (meth) carbamate is improved, the reaction steps are few, and the intermediate and the target compound prepared from the route can be directly purified through recrystallization. (by machine translation)