1349699-52-0

Upstream product

• 624-31-7 4-tolyl iodide 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 
• 693-02-7 hex-1-yne 
• 1349699-37-1 3-n-butyl-5-(4-methylphenyl)-4,5-dihydroisoxazole 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 5775-76-8 valeraldoxime 

Relevant academic research and scientific papers

Phosphine- and copper-free palladium catalyzed one-pot four-component carbonylation reaction for the synthesis of isoxazoles and pyrazoles

The palladium catalyzed one-pot synthesis of isoxazoles and pyrazoles from aryl iodides, terminal alkynes, chromium hexacarbonyl and hydroxylamine hydrochloride or aqueous hydrazine solution is described. The Sonogashira carbonylative coupling intermediate was trapped in situ by hydroxylamine hydrochloride or aqueous hydrazine to deliver isoxazoles or pyrazoles, respectively, in high yields. This efficient method proceeds at atmospheric pressure and moderate temperature and does not require the use of copper, phosphine ligands or gaseous carbon monoxide.

Expeditious preparation of isoxazoles from Δ2-isoxazolines as advanced intermediates for functional materials

A collection of isoxazoles derivatives has been efficiently synthesized in three steps. The oximation reaction of aldehydes followed by nitrile oxide [3+2] 1,3-dipolar cycloaddition and MnO2-oxidation reaction furnished the title compounds which were purified by simple filtration on celite.