134970-49-3 Usage
Description
8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester, also known as ethyl 8-hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylate, is a chemical compound with the molecular formula C11H16O5. It is an ester derivative of 8-hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid, characterized by its unique chemical structure and properties. 8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester is commonly utilized in organic synthesis and pharmaceutical research, and it holds potential for the development of new drugs and pharmaceuticals.
Uses
Used in Pharmaceutical Research:
8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester serves as a versatile building block for the development of complex organic molecules. Its reactivity and functional groups make it a valuable component in the synthesis of a wide range of organic compounds.
Used in Drug Development:
8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester is used as a precursor in the development of new drugs. Its unique chemical properties enable the design and synthesis of novel pharmaceutical agents with potential applications in various therapeutic areas.
It is important to handle 8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester with care, as it may pose health and safety risks if not used properly. Proper safety measures and precautions should be taken during its synthesis, storage, and use to minimize any potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 134970-49-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,9,7 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 134970-49:
(8*1)+(7*3)+(6*4)+(5*9)+(4*7)+(3*0)+(2*4)+(1*9)=143
143 % 10 = 3
So 134970-49-3 is a valid CAS Registry Number.
134970-49-3Relevant articles and documents
Discovery and optimization of selective RET inhibitors via scaffold hopping
Luo, Zhibo,Wang, Lingli,Fu, Zhifei,Shuai, Bin,Luo, Miaorong,Hu, Guoping,Chen, Jian,Sun, Jikui,Wang, Jiansong,Li, Jian,Chen, Shuhui,Zhang, Yang
, (2021)
Aberrant alterations of rearranged during transfection (RET) have been identified as actionable drivers of multiple cancers, including thyroid carcinoma and lung cancer. Currently, several approved multikinase inhibitors such as vandetanib and cabozantinib demonstrate clinical activity in patients with RET-rearranged or RET-mutant cancers. However, the observed response rates are only modest and the ‘off-target’ toxicities resulted from the inhibition of other kinases is also a concern. Herein, we designed and synthesized a series of RET inhibitors based on the structure of selective RET inhibitor BLU-667 and investigated their biological activities. We identified compound 9 as a novel potent and selective RET inhibitor with improved drug-like properties. Compound 9 exhibits a selective inhibitory profile with an inhibitory concentration 50 (IC50) of 1.29 nM for RET and 1.97 (RET V804M) or 0.99 (RET M918T) for mutant RETs. The proliferation of Ba/F3 cells transformed with NSCLC related KIF5B-RET fusion was effectively suppressed by compound 9 (IC50 = 19 nM). Additionally, compound 9 displayed less ‘off-target’ effects than BLU-667. In mouse xenograft models, compound 9 repressed tumor growth driven by KIF5B-RET-Ba/F3 cells in a dose-dependent manner. Based on its exceptional kinase selectivity, good potency and high exposure in tumor tissues, compound 9 represents a promising lead for the discovery of RET directed therapeutic agents and the study of RET-driven tumor biology.
