1349798-07-7Relevant academic research and scientific papers
Accelerating Amine-Catalyzed Asymmetric Reactions by Intermolecular Cooperative Thiourea/Oxime Hydrogen-Bond Catalysis
Afewerki, Samson,Córdova, Armando,Ibrahem, Ismail,Ma, Guangning,Zhang, Kaiheng
supporting information, p. 3043 - 3049 (2021/07/22)
The ability of intermolecular cooperative thiourea/oxime hydrogen-bond catalysis for improving and accelerating asymmetric aminocatalysis is presented. The two readily available hydrogen-bond-donating catalysts operates in synergy with a chiral amine catalyst to accomplish highly stereoselective transformations. The synergistic catalyst systems simultaneously activate both electrophiles and nucleophiles, and make the transformations more chemo- and stereoselective. This was exemplified by performing co-catalytic enantioselective direct intermolecular α-alkylation reactions of aldehydes, direct aldol reactions, and asymmetric conjugate reactions, which gave the corresponding products in high yields and enantiomeric ratios.
Merging organocatalysis with transition metal catalysis: Highly stereoselective α-alkylation of aldehydes
Xiao, Jian
supporting information; experimental part, p. 1716 - 1719 (2012/06/18)
The unprecedented cooperative systems involving a diarylprolinol silyl ether with various Lewis acids have been found to effect the highly enantioselective intermolecular α-alkylation of aldehydes. A wide variety of aldehydes and alcohols can be transformed into the desired highly functionalized aldehydes in high yields, excellent enantioselectivities, and good diastereoselectivities at room temperature under mild conditions.
Highly enantioselective intermolecular alkylation of aldehydes with alcohols by cooperative catalysis of diarylprolinol silyl ether with Bronsted acid
Xiao, Jian,Zhao, Kai,Loh, Teck-Peng
supporting information; experimental part, p. 2890 - 2894 (2012/07/03)
Two cooperative systems: I/2,3,4-trihydroxybenzoic acid and I/TfOH effect highly enantioselective intermolecular α-alkylation of aldehydes. These systems afford functionalized aldehydes in high yields, and with excellent ee and de values with broad substrate scope (see scheme; R1=alkyl, R2,R3=aryl, or R2=ferrocenyl, R 3=phenyl, or R2=indolyl, R3=phenyl).
