1349798-32-8

Basic information

• Product Name: C₂₀H₂₆N₂O₂
• CAS NO: 1349798-32-8
• Molecular Weight: 326.439
• Mol File: 1349798-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₆N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₆N₂O₂(1349798-32-8)
• EPA Substance Registry System: C₂₀H₂₆N₂O₂(1349798-32-8)

Safety Data

• Hazardous Substances Data: 1349798-32-8(Hazardous Substances Data)

Upstream product

• 13466-38-1 5-bromopyridin-2(1H)-one 
• 1349798-37-3 C₁₅H₁₆ClNO₂ 
• 41720-98-3 (R)-2-methylpyrrolidine hydrochloride 
• 1349798-36-2 C₁₂H₁₁NO₂ 
• 81971-39-3 5-bromo-1-methylpyridin-2(1H)-one 

Relevant articles and documents

Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists

6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]-phenyl}-2H-pyridazin-3-one 6 (Irdabisant; CEP-26401) was recently reported as a potent H3R antagonist with excellent drug-like properties and in vivo activity that advanced into clinical evaluation. A series of pyridone analogs of 6 was synthesized and evaluated as H3R antagonists. Structure-activity relationships revealed that the 5-pyridone regiomer was optimal for H 3R affinity. N-Methyl 9b showed excellent H3R affinity, acceptable pharmacokinetics and pharmaceutical properties. In vivo evaluation of 9b showed potent activity in the rat dipsogenia model and robust wake-promoting activity in the rat EEG model.