1349807-46-0 Usage
Description
FMoc-N-Me-D-Cys(Trt)-OH, also known as 9-fluorenylmethoxycarbonyl-N-methyl-D-cysteine trityl, is a chemical compound that serves as a protected form of L-cysteine. It is characterized by the presence of a fluorenylmethoxycarbonyl (Fmoc) group, which is a widely used protecting group in peptide synthesis, and a trityl (Trt) group, which is a bulky protecting group that shields the thiol functionality of the cysteine residue. FMoc-N-Me-D-Cys(Trt)-OH is essential in the field of organic chemistry and biochemistry, particularly in the synthesis of peptides and proteins.
Uses
Used in Peptide Synthesis:
FMoc-N-Me-D-Cys(Trt)-OH is used as a protected amino acid building block for the solid-phase synthetic preparation of peptides. The Fmoc group allows for the stepwise addition of amino acids during peptide synthesis, while the Trt group protects the thiol group of the cysteine residue from unwanted side reactions, ensuring the correct formation of disulfide bonds and maintaining the desired peptide structure.
Used in Thioesterification of Peptides:
FMoc-N-Me-D-Cys(Trt)-OH is also used as a thioesterification agent in peptide synthesis. Thioesterification is a process that involves the formation of a thioester bond between a peptide and a thiol group, which can be useful for various applications, such as the synthesis of cyclic peptides, the preparation of peptide-protein conjugates, and the development of novel drug delivery systems.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, FMoc-N-Me-D-Cys(Trt)-OH is used as a key intermediate in the synthesis of various therapeutic peptides and proteins. The compound's ability to protect the thiol group of cysteine residues during peptide synthesis is crucial for the development of drugs that target specific biological pathways, such as those involved in cancer, inflammation, and other diseases.
Used in Research and Development:
FMoc-N-Me-D-Cys(Trt)-OH is also utilized in research and development laboratories for the synthesis and modification of peptides and proteins. Its role in protecting the thiol group of cysteine residues allows researchers to explore new peptide-based therapeutics, develop novel drug delivery systems, and study the structure and function of proteins in greater detail.
Check Digit Verification of cas no
The CAS Registry Mumber 1349807-46-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,9,8,0 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1349807-46:
(9*1)+(8*3)+(7*4)+(6*9)+(5*8)+(4*0)+(3*7)+(2*4)+(1*6)=190
190 % 10 = 0
So 1349807-46-0 is a valid CAS Registry Number.
1349807-46-0Relevant articles and documents
Isostearyl Mixed Anhydrides for the Preparation of N-Methylated Peptides Using C-Terminally Unprotected N-Methylamino Acids
Cary, Douglas R.,Handa, Michiharu,Kobayashi, Yutaka,Kurasaki, Haruaki,Masuya, Keiichi,Matsuda, Ayumu,Matsumoto, Masatoshi,Morimoto, Koki,Nagaya, Akihiro,Nishizawa, Naoki,Taguri, Tomonori,Takeuchi, Hisayuki
, p. 8039 - 8043 (2020/11/02)
Sustainable and efficient manufacturing methods for N-methylated peptides remain underexplored despite growing interest in therapeutic N-methylated peptides within the pharmaceutical industry. A methodology for the coupling of C-terminally unprotected N-methylamino acids mediated by an isostearic acid halide (ISTAX) and silylating reagent has been developed. This approach allows for the coupling of a wide variety of amino acids and peptides in high yields under mild conditions without the need for a C-terminal deprotection step in the process of C-terminal elongation. These advantages make this a useful synthetic method for the production of peptide therapeutics and diagnostics containing N-methylamino acids.
N-Alkyl cysteine-assisted thioesterification of peptides
Hojo, Hironobu,Onuma, Yuko,Akimoto, Yuri,Nakahara, Yuko,Nakahara, Yoshiaki
, p. 25 - 28 (2007/10/03)
A new method for the preparation of peptide thioester by the post-solid phase peptide synthesis (SPPS) approach was developed. A series of N-alkyl cysteine derivatives were prepared and used as the C-terminus residue of the peptides prepared by the Fmoc S
