134988-41-3Relevant academic research and scientific papers
Efficient Monofluoroalkylation of Thiophenols or Phenols with α-Bromo-α-Fluoroketones under Mild Conditions
Li, Zhi,Fang, Mougui,Wu, Jingjing,Liu, Yunli,Liu, Yecheng,Wu, Fanhong
, p. 2293 - 2303 (2021/03/16)
An efficient nucleophilic substitution reaction between α-bromo-α-fluoroketones and thiophenols or phenols is reported for the synthesis of α-fluoro-β-ketosulfides or α-fluoro-β-ketone ethers in yields ranging from 78-93%. This method exhibits good functional group tolerance and a broad scope of nucleophilic substrates, including natural phenolic compounds.
A Route to α-Fluoroalkyl Sulfides from α-Fluorodiaroylmethanes
Lin, Ya-Mei,Yi, Wen-Bin,Shen, Wan-Zhao,Lu, Guo-Ping
supporting information, p. 592 - 595 (2016/02/18)
α,α-Difluorodiaroylmethane can be used as a nucleophilic difluoromethylation reagent for generating α-thioaryl-α,α-difluoroacetophenones (Ar1COCF2SAr) and difluoromethylthiolated arenes (ArSCF2H) under transition-metal-free conditions. The reaction selectivity is mainly dependent on temperature. The method has also been extended to the synthesis of α-thioaryl-α-monofluoroacetophenones using α-monofluorodibenzoylmethane. Moreover, the benzoyl cation derived from α,α-difluorodibenzoylmethane can react with nucleophiles to afford the desired products in a one-pot process.
Electrolytic Partial Fluorination of Organic Compounds. 17. Regiospecific Anodic Fluorination of Sulfides Bearing Electron-Withdrawing Substituents at the Position α to the Sulfur Atom
Fuchigami, Toshio,Shimojo, Moriyasu,Konno, Akinori
, p. 3459 - 3464 (2007/10/02)
Regiospecific monofluorination of various sulfides bearing electron-withdrawing substituents, cyano, ester, acyl, amino, and phosphonate groups, at their α-positions was successfully carried out by the anodic oxidation of the sulfides in Et3N*3HF/MeCN usi
OXIDATIVE FLUORINATION OF SULFIDES IN PRESENCE OF Et3N*3HF
Brigaud, Thierry,Laurent, Andre,Laurent, Eliane
, p. 153 - 156 (2007/10/02)
Electrochemical oxidation of sulfides produces sulfonium ions.The reactivity of these ions versus fluoride anions is described.
Oxidative fluorination of sulfides in presence of Et3N.3HF
Brigaud,Laurent
, p. 2287 - 2290 (2007/10/02)
The synthesis of fluorocompounds by sulfide electrochemical oxidation using Et3N.3HF as fluorinating agent is described. Chemical oxidation (DBH) is less efficient.
