1349889-66-2Relevant academic research and scientific papers
Synthesis, antioxidant and anticancer activity of 2-amino-4-methyl-1,3- oxazole-5-carboxylic acid derivatives of amino acids and peptides
Himaja,Ranjitha
, p. 13 - 18 (2013/09/24)
A new series of novel 2-amino-4-methyl-1,3-oxazole-5-carboxylamino acid and peptide derivatives (6a-c; 8a&b) were synthesized by using O-(benzotriazol-l-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (TBTU) as coupling reagent. The key intermediate 2-amino-4-methyl-1,3-oxazole-5-carboxylic acid 4 was synthesized by the condensation of urea 1 with ethyl 2-chloroacetoacetate 2 followed by basic hydrolysis. The structure of the newly synthesized compounds were confirmed by FT-IR, 1H NMR and Mass spectral analysis. The compounds were evaluated for their antioxidant and anticancer activities. Some of the synthesized compounds have shown potent antioxidant activities. A few compounds have shown significant anticancer activity against HT-29 cancer cell lines.
