79221-15-1

Usage

Uses

Ethyl 2-amino-4-methyloxazole-5-carboxylate

Upstream product

• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 78451-11-3 ethyl 2-chloro-4-methyloxazole-5-carboxylate 
• 1349889-66-2 C₁₆H₁₈N₄O₆ 

Relevant academic research and scientific papers

THERAPEUTIC INHIBITORY COMPOUNDS

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases

SUBSTITUTED INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS

The present invention provides substituted indazole compound of formula (I) and pharmaceutically acceptable salts thereof, and their use to inhibit IRAK4 and/or for the treatment of diseases or disorders induced by IRAK4.

PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS

The present invention provides DNA Gyrase and/or Topo IV inhibitors of Formula (I), which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Mvraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotynebacterium, Bacillus spp., Enterobactericeae (E. coli, Klebsiella spp., Proteus spp., etc.) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.

Synthesis, antioxidant and anticancer activity of 2-amino-4-methyl-1,3- oxazole-5-carboxylic acid derivatives of amino acids and peptides

A new series of novel 2-amino-4-methyl-1,3-oxazole-5-carboxylamino acid and peptide derivatives (6a-c; 8a&b) were synthesized by using O-(benzotriazol-l-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (TBTU) as coupling reagent. The key intermediate 2-amino-4-methyl-1,3-oxazole-5-carboxylic acid 4 was synthesized by the condensation of urea 1 with ethyl 2-chloroacetoacetate 2 followed by basic hydrolysis. The structure of the newly synthesized compounds were confirmed by FT-IR, 1H NMR and Mass spectral analysis. The compounds were evaluated for their antioxidant and anticancer activities. Some of the synthesized compounds have shown potent antioxidant activities. A few compounds have shown significant anticancer activity against HT-29 cancer cell lines.

PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS

The present invention provides DNA Gyrase and/or Topo IV inhibitors of formula I, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Muraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotyne bacterium, Bacillus spp., Enterobactericeae (E.coli, Klebsiella spp., Proteus spp.,etc.) or any combination thereof Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections