134989-50-7

Basic information

• Product Name: 4-Nitro-benzenesulfonate7-ethoxy-1-methyl-3,4,5,6-tetrahydro-2H-azepinium;
• Synonyms: 4-Nitro-benzenesulfonate7-ethoxy-1-methyl-3,4,5,6-tetrahydro-2H-azepinium
• CAS NO: 134989-50-7
• Molecular Weight: 358.415
• Mol File: 134989-50-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Nitro-benzenesulfonate7-ethoxy-1-methyl-3,4,5,6-tetrahydro-2H-azepinium;(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-benzenesulfonate7-ethoxy-1-methyl-3,4,5,6-tetrahydro-2H-azepinium;(134989-50-7)
• EPA Substance Registry System: 4-Nitro-benzenesulfonate7-ethoxy-1-methyl-3,4,5,6-tetrahydro-2H-azepinium;(134989-50-7)

Safety Data

• Hazardous Substances Data: 134989-50-7(Hazardous Substances Data)

Upstream product

• 1670-47-9 1,1-diethoxycyclohexane 
• 85462-16-4 N-Methyl-O-p-nitrophenylsulphonylhydroxylamine 

Downstream Products

• 2556-73-2 1-methyl-2-azepanone 

Relevant articles and documents

A simple, one-flask transformation of ketones to N-methyl lactams

A one-flask conversion of cyclic ketones to N-methyl lactams is described. Reaction of the ketone with triethylorthoformate generates an acetal which is reacted in situ with N-(((p-nitrobenzene)sulfonyl)oxy methylamine 2a(CH3NH-OSO2C6H4NO2). Dealkylation of the resulting O-ethyl imidate with sodium iodide gives the lactam. A variety of lactams, including macrocyclic lactams, are produced simply and in good yields.