1349901-46-7

Upstream product

• 163082-04-0 (1R,4S,5S,6R)-3-bromo-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene 
• 154784-39-1 (3aS,7aS)-4-iodo-2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole 
• 138769-92-3 cis-(1S,2S)-1,2-dihydroxy-3-iodocyclohexa-3,5-diene 
• 130669-75-9 (3aS,7aS)-4-bromo-2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole 
• 67451-62-1 cis-(1S,2S)-1,2-dihydroxy-3-bromocyclohexa-3,5-diene 
• 1349901-43-4 C₁₉H₂₆N₂O₆S 
• 1196490-97-7 ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate 
• 1196490-93-3 ethyl (3aS,4R,5R,7aR)-2,2-dimethyl-8-[(4-methylphenyl)-sulfonyl]-3a,4,5,7a-tetrahydro-4,5-epimino-1,3-benzodioxole-7-carboxylate 
• 1349901-49-0 tert-butyl ((3aS,4R,5S,7aS)-7-iodo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate 
• 1196491-69-6 tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate 
• 1349901-42-3 C₁₆H₂₁BrN₂O₄S 
• 1349901-48-9 N-[(3aS,4R,5S,7aS)-5-azido-7-iodo-2,2-dimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-4-yl]-4-methylbenzenesulfonamide 
• 1196491-67-4 N-[(3aS,4R,5S,7aS)-5-azido-7-bromo-2,2-dimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-4-yl]-4-methylbenzenesulfonamide 
• 1349901-47-8 C₁₆H₁₈INO₄S 

Relevant academic research and scientific papers

Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): Evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics

Four generations of chemoenzymatic approaches to oseltamivir are presented. The first two generations relied on the use of cyclohexadiene-cis-diol derived enzymatically from bromobenzene. The third and fourth generation used the corresponding diol obtaine