1349901-48-9

Upstream product

• 1349901-47-8 C₁₆H₁₈INO₄S 
• 138769-92-3 cis-(1S,2S)-1,2-dihydroxy-3-iodocyclohexa-3,5-diene 
• 154784-39-1 (3aS,7aS)-4-iodo-2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole 

Downstream Products

• 1349901-49-0 tert-butyl ((3aS,4R,5S,7aS)-7-iodo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate 
• 1196491-05-0 ethyl (3aR,6S,7R,7aS)-6-[(tert-butoxycarbonyl)amino]-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate 
• 1196491-09-4 ethyl (3aR,4R,6S,7R,7aS)-6-[(tert-butoxycarbonyl)amino]-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}hexahydro-1,3-benzodioxole-4-carboxylate 
• 1196491-13-0 ethyl (3R,4R,5S)-5-((tert-butoxycarbonyl)amino)-3-hydroxy-4-(4-methylphenylsulfonamido)cyclohex-1-ene carboxylate 
• 1349901-46-7 C₂₁H₃₂N₂O₇S 

Relevant academic research and scientific papers

Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): Evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics

Four generations of chemoenzymatic approaches to oseltamivir are presented. The first two generations relied on the use of cyclohexadiene-cis-diol derived enzymatically from bromobenzene. The third and fourth generation used the corresponding diol obtaine