1349902-20-0

Usage

Uses

Used in Pharmaceutical Industry:
2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid is used as a potential antiviral agent for its ability to inhibit viral replication and reduce the severity of viral infections.
2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid is used as a potential antitumor agent for its potential to inhibit tumor growth and proliferation, making it a candidate for cancer treatment.
2,3,4,5,6,7-hexahydro-4-oxo-2-thioxo-1H-CyclopentapyriMidine-1-acetic acid is used as a potential treatment for inflammation and oxidative stress-related conditions due to its potential to modulate inflammatory responses and reduce oxidative stress in the body.

Upstream product

• 1349902-19-7 sodium ({2-[(methyloxy)carbonyl]-1-cyclopenten-1-yl}amino)acetate 
• 540-72-7 sodium thiocyanide 
• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 6000-44-8 sodium glycinate 

Downstream Products

• 356058-42-9 {2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}acetic acid 
• 356057-34-6 N-[2-(diethylamino)ethyl]-2-(2-{[(4-fluorophenyl)methyl]thio}-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-{[4’-(trifluoromethyl)-4-biphenylyl]methyl}acetamide 

Relevant academic research and scientific papers

RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS

The present inventors have developed new radiolabeled Darapladib and analogs thereof which can be used for the specific detection of vulnerable atherosclerotic plaques by targeting lipoprotein-associated phospholipase A2 (Lp-PLA2) which is a biomarker of

Regioselectivity of thiouracil alkylation: Application to optimization of Darapladib synthesis

Darapladib is one of the most potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 0.25 nM. We demonstrate that a crucial step of Darapladib synthesis was not correctly described in the litera

Selective inhibitors and tailored activity probes for lipoprotein- associated phospholipase A2

Lipoprotein-associated phospholipase A2 (Lp-PLA2 or PLA2G7) binds to low-density lipoprotein (LDL) particles, where it is thought to hydrolyze oxidatively truncated phospholipids. Lp-PLA2 has also been implicate

NOVEL PROCESSES

This invention relates to methods of making a compound of formula (I) and intermediates for same. The compounds of formula (I) being useful for treating cardiovascular and inflammatory diseases such as atherosclerosis.