134997-87-8 Usage
Description
3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-6-CARBOXYLIC ACID, also known as 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylic acid, is a chemical compound with a complex molecular structure. It is characterized by its unique properties, which make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-6-CARBOXYLIC ACID is used as a poly(ADP-ribose) polymerase (PARP) inhibitor for the treatment of various diseases. PARP inhibitors play a crucial role in the treatment of certain types of cancer by targeting the PARP enzyme, which is involved in the repair of DNA damage. By inhibiting this enzyme, the compound can potentially enhance the effectiveness of cancer therapies and improve patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 134997-87-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,9,9 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 134997-87:
(8*1)+(7*3)+(6*4)+(5*9)+(4*9)+(3*7)+(2*8)+(1*7)=178
178 % 10 = 8
So 134997-87-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7NO4/c11-8-4-14-7-2-1-5(9(12)13)3-6(7)10-8/h1-3H,4H2,(H,10,11)(H,12,13)
134997-87-8Relevant articles and documents
NEW HETEROCYCLIC COMPOUNDS
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Page/Page column 67-68, (2019/06/17)
The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
SMYD INHIBITORS
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Paragraph 0850; 0853-0855, (2017/07/18)
The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
MORPHOLINYL AND PYRROLIDINYL ANALOGS
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Page/Page column 122-123, (2008/06/13)
The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.