1349979-96-9Relevant academic research and scientific papers
Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain
Beebe, Xenia,Yeung, Clinton M.,Darczak, Daria,Shekhar, Shashank,Vortherms, Timothy A.,Miller, Loan,Milicic, Ivan,Swensen, Andrew M.,Zhu, Chang Z.,Banfor, Patricia,Wetter, Jill M.,Marsh, Kennan C.,Jarvis, Michael F.,Scott, Victoria E.,Schrimpf, Michael R.,Lee, Chih-Hung
, p. 4857 - 4861 (2013/09/02)
A novel series of N-type calcium channel inhibitors have been discovered. Optimization of potency and HT-ADME properties provides 4- aminocyclopentapyrrolidines with analgesic efficacy after oral dosing.
