135038-13-0Relevant articles and documents
Asymmetric synthesis of anticancer β-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate
Banik, Bimal K.,Banik, Indrani,Becker, Frederick F.
, p. 846 - 848 (2010)
We describe herein asymmetric synthesis of a novel anticancer β-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these β-lactams are also reported here.
An asymmetric synthesis of a 3-hydroxy-β-lactam by keteneimine cycloaddition: Utilization of chiral ketenes from carbohydrates
Borer, Bennett C.,Balogh, Douglas W.
, p. 1039 - 1040 (2007/10/02)
The Staudinger reaction of a chiral carbohydrate-based ketene and an imine proceeds to give, after removal of the sugar, cis-3-hydroxy-β-lactam 7 in moderate yield with good asymmetric induction (70% e.e.).