13504-90-0

Basic information

• Product Name: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)
• CAS NO: 13504-90-0
• Molecular Formula: C23H23NO7S2
• Molecular Weight: 489.57
• Mol File: 13504-90-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(13504-90-0)
• EPA Substance Registry System: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(13504-90-0)

Safety Data

• Hazardous Substances Data: 13504-90-0(Hazardous Substances Data)

Upstream product

• 60-18-4 L-tyrosine 
• 98-59-9 p-toluenesulfonyl chloride 
• 13504-89-7 (S)-(O)-Ts-Tyr-OH 

Downstream Products

• 106-45-6 para-thiocresol 
• 4703-32-6 (S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid 
• 1361127-77-6 (S,E)-ethyl 3-(N-(4-diazo-3-oxo-1-(4-(tosyloxy)phenyl)butan-2-yl)-4-methylphenylsulfonamido)acrylate 
• 1361127-15-2 (1S,3S,5S,6S)-ethyl 4-oxo-2-tosyl-3-(4-(tosyloxy)benzyl)-2-azabicyclo[3.1.0]hexane-6-carboxylate 
• 1361127-25-4 (1S,3R,5S,6S)-ethyl 4-oxo-2-tosyl-3-(4-(tosyloxy)benzyl)-2-azabicyclo[3.1.0]hexane-6-carboxylate 
• 1361126-95-5 (S,E)-2-(N-(3-ethoxy-3-oxoprop-1-enyl)-4-methylphenylsulfonamido)-3-(4-(tosyloxy)phenyl)propanoic acid 
• 103211-81-0 N-[N,O-bis-(toluene-4-sulfonyl)-L-tyrosyl]-glycine methyl ester 

Relevant articles and documents

Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy

AIMP2-DX2, a splicing variant of AIMP2, is up-regulated in lung cancer, possesses oncogenic activity, and results in tumorigenesis. Specifically inhibiting the interaction between AIMP2-DX2 and HSP70 to suppress AIMP2-DX2-dependent cancers with small molecules is considered a promising avenue for cancer therapeutics. Optimization of hit BC-DXI-04 (IC50 = 40.1 μM) provided new potent sulfonamide based AIMP2-DX2 inhibitors. Among these, BC-DXI-843 showed improved inhibition against AIMP2-DX2 (IC50 = 0.92 μM) with more than 100-fold selectivity over AIMP2 in a luciferase assay. Several binding assays indicated that this compound effectively induces cancer cell apoptosis by specifically interrupting the interaction between DX2 and HSP70, which leads to the degradation of DX2 via Siah1-mediated ubiquitination. More importantly, BC-DXI-843 demonstrated in vivo efficacy in a tumor xenograft mouse model (H460 cells) at a dosage of 50 mg/kg, suggesting it as a promising lead for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.

Metal-Free N–H/C–H Coupling for Efficient Asymmetric Synthesis of Chiral Dihydroquinoxalinones from Readily Available α-Amino Acids

We have developed a method for the synthesis of dihydroquinoxalinones via intramolecular N–H/C–H coupling using hypervalent iodine. The starting materials were prepared from inexpensive and readily available aniline and amino acid derivatives. Various functional groups were tolerated to give multisubstituted dihydroquinoxalinones in moderate to excellent yields. The chirality of the amino acid was transferred to the desired target compound without a loss of enantiomeric excess. Preliminary mechanistic studies indicated that the reaction proceeds via an ionic mechanism.

PARA-QUINOL DERIVATIVES AND METHODS OF STEREO SELECTIVELY SYNTHESIZING AND USING SAME

This application relates to para-quinol derivatives, such as analogues of manumycins, aranorosins and gymnastatins. This application also relates to methods of synthesizing and using the para-quinol derivatives. In one embodiment of the invention a compou