135042-87-4Relevant academic research and scientific papers
New Ligands Double the Scope of the Catalytic Asymmetric Dihydroxylation of Olefins
Sharpless, K. Barry,Amberg, Willi,Beller, Matthias,Chen, Hou,Hartung, Jens,et al.
, p. 4585 - 4588 (1991)
Improved ligands render terminal olefins good substrates for the osmium-catalyzed asymmetric dihydroxylation (ADH) process, and the amounts of chiral ligand and osmium catalyst required diminish dramatically.
Resolution of diols via catalytic asymmetric acetalization
Kim, Ji Hye,ori, Ilija,Palumbo, Chiara,List, Benjamin
, p. 1778 - 1781 (2015/03/04)
A highly enantioselective kinetic resolution of diols via asymmetric acetalization has been achieved using a chiral confined imidodiphosphoric acid catalyst. The reaction is highly efficient for the resolution of tertiary alcohols, giving selectivity factors of up to >300. Remarkably, even in cases where the selectivity factors are only moderate, highly enantioenriched diols are obtained via a stereodivergent resolution to diastereomeric acetals.
