1350432-89-1Relevant academic research and scientific papers
Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of τ-pathology
Riss, Patrick J.,Brichard, Laurent,Ferrari, Valentina,Williamson, David J.,Fryer, Tim D.,Hong, Young T.,Baron, Jean-Claude,Aigbirhio, Franklin I.
, p. 852 - 855 (2013)
Formation of neurofibrillary tangles, comprising of microtubule-associated tau protein, is a hallmark of a group of neurodegenerative diseases, including Alzheimer's disease. In consequence, in vivo imaging of neurofibrillary tangles is a current focus of positron emission tomography research. Herein, development of an in vitro radioligand binding assay which uses synthetic aggregates as a model of neurofibrillary tangles is reported, together with evaluation of novel derivatives of the tau protein ligand astemizole. The Royal Society of Chemistry 2013.
