433-06-7

Basic information

• Product Name: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE
• Synonyms: P-TOLUENESULFONIC ACID 2,2,2-TRIFLUOROETHYL ESTER;TRIFLUORETHYLTOSYLATE;TRIFLUOROETHANOL TOSYLATE;2,2,2-TRIFLUOROETHYL P-TOLUENESULF;2,2,2-trifluoroethyl ester;2,2,2-trifluoro-, p-toluenesulfonate;o-(p-tosyl)a,a,a,-trifluoroethanol;2,2,2-Trifluoroethyl 4-methylbenzenesulphonate, 2,2,2-Trifluoroethyl tosylate
• CAS NO: 433-06-7
• Molecular Formula: C₉H₉F₃O₃S
• Molecular Weight: 254.23
• EINECS: 207-085-5
• Product Categories: blocks;BuildingBlocks;FluoroCompounds;API intermediates;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Organic Building Blocks;Sulfur Compounds;Tosylates
• Mol File: 433-06-7.mol
• Article Data: 50

Chemical Properties

• Melting Point: 36-38 °C(lit.)
• Boiling Point: 87-92 °C0.1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: White crystalline solid
• Density: 1 g/cm3
• Vapor Pressure: 0.00418mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Sparingly), Methanol (Sparingly)
• Sensitive: Moisture Sensitive
• BRN: 2699394
• CAS DataBase Reference: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE(433-06-7)
• EPA Substance Registry System: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE(433-06-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 433-06-7(Hazardous Substances Data)

Usage

Chemical Properties

WHITE CRYSTALLINE SOLID

Uses

2,2,2-Trifluoroethyl Tosylate is a trifluoroethylation agent used in the preparation of 2,2,2-trifluoroethyl phenyl sulfone, a potential 2,2,2-trifluoroethyl pronucleophile.

InChI:InChI=1/C7H8FNO2S/c1-9-12(10,11)7-4-2-6(8)3-5-7/h2-5,9H,1H3

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 17721-45-8 1-tosylazepane 
• 4703-22-4 N-tosylpiperidine 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 98-59-9 p-toluenesulfonyl chloride 
• 166903-46-4 1-[hydroxy(tosyloxy)iodo]-1H,1H-perfluoroethane 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 104-15-4 toluene-4-sulfonic acid 
• 25370-91-6 N-benzyl-N'-(4-toluenesulfonyloxy)diimide N-oxide 
• 288-32-4 1H-imidazole 

Downstream Products

• 143264-59-9 1-(1-Difluoromethylene-pentyl)-4-nitro-benzene 
• 134024-31-0 m-tolyl 2,2,2-trifluoroethyl sulfide 
• 195734-31-7 o-(1,1-difluoro-3-methylpent-1-en-2-yl)aniline 
• 87014-28-6 1-(2,2,2-trifluoroethoxy)-2-nitrobenzene 
• 123455-91-4 (5,5-difluoropent-4-en-2-yl)benzene 
• 134134-76-2 (4,4-difluorobut-3-en-1-yl)benzene 
• 324741-27-7 1-(t-Butoxycarbonyl)-4-[2-methoxy-5-(2,2,2-trifluoroethoxy)-phenyl]piperazine 
• 334929-98-5 5-Fluoro-2-(2,2,2-trifluoroethoxy)-nitrobenzene 
• 57946-60-8 2-(2',2',2'-trifluoroethoxy)aniline 
• 80054-80-4 1-chloro-4-(2,2,2-trifluoroethoxy)benzene 
• 56738-90-0 1-(3-nitro-phenyl)-3-(2,2,2-trifluoro-ethyl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione 
• 126767-47-3 5-(4-Chlorophenyl)-2-(2,2,2-trifluoroethylthio)oxazole 
• 918483-25-7 1-(3-bromophenyl)-2-[1-(2,2,2-trifluoroethyl)-1H-pyrrol-3-yl]ethane-1,2-dione 
• 335022-88-3 1-{(2S,3R)-2-hydroxy-5-[2-(2,2,2-trifluoroethoxy)phenyl]-3-pentyl}imidazole-4-carboxamide 

Relevant articles and documents

Synthesis of new fluorinated imidazolium ionic liquids and their prospective function as the electrolytes for lithium-ion batteries

Two fluorine-containing ionic liquids, 1-(2,2,2-trifluoroethyl)-3- methylimidazolium tosylate and 1-(2,2,2-trifluoroethyl)-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (TFSI anion), were obtained in good yields and high purity via a green pathway procedure free of solvent and hazardous catalyst. The incorporation of CF3 moieties in imidazolium structure decreases the ILs TFSI melting point. The preliminary electrochemical results are very promising, a wide electrochemical stability up to 5.7 V vs Li +/Li for the fluorinated imidazolium with TFSI anion.

KIF18A INHIBITORS

Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Palladium-Catalyzed Fluoroarylation of gem-Difluoroenynes to Access Trisubstituted Trifluoromethyl Allenes

Various new transformations of gem-difluoroalkenes leading to trifluoromethyl substituted compounds have been well established in the past years. However, the development of new transformations of gem-difluoroenynes lags much behind. Herein is reported the fluoroarylation of 1,1-difluoro-1,3-enynes with aryl halides in the presence of silver fluoride affording trisubstituted trifluoromethyl allenes under the catalysis of palladium. The reaction features mild conditions, high functional-group tolerance, and high regioselectivity.