1350466-25-9Relevant academic research and scientific papers
Enantioselective Synthesis of 3-Substituted 3-Amino-2-oxindoles by Amination with Anilines
Yang, Wenkun,Dong, Pei,Xu, Jian,Yang, Jian,Liu, Xiaohua,Feng, Xiaoming
, p. 9272 - 9275 (2021)
A chiral N,N′-dioxide-nickel(II) complex-catalyzed asymmetric amination of 3-bromo-3-substituted oxindoles with anilines has been developed. A series of alkyl or aryl 3-amino-indolinones with quaternary stereocenters were obtained in high yields with excellent ee values in one step (up to 99 % yield, up to 96 % ee). The method provided a ready route to optically active intermediates of 3-amino-2-oxindole-based bioactive compounds. Moreover, a possible transition-state model is proposed so as to elucidate the origin of the chirality based on the X-ray crystal structure of the catalyst and the adduct.
A Hg(ClO4)2 3 3H2O Catalyzed sakurai-hosomi allylation of isatins and isatin ketoimines using allyltrimethylsilane
Cao, Zhong-Yan,Zhang, Yan,Ji, Cong-Bin,Zhou, Jian
supporting information; experimental part, p. 6398 - 6401 (2012/02/02)
It is reported that Hg(ClO4)2 3 3H2O could efficiently activate the cheap but less reactive allyltrimethylsilane for the allylation of isatins or isatin ketoimines, with catalyst loading down to 0.1 mol %. This is the firs
