1350474-91-7

Basic information

• Product Name: C₁₅H₂₁N₂O⁽¹⁺⁾*I^(1-)
• Synonyms: C₁₅H₂₁N₂O⁽¹⁺⁾*I^(1-)
• CAS NO: 1350474-91-7
• Molecular Weight: 372.249
• Mol File: 1350474-91-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₂₁N₂O⁽¹⁺⁾*I^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₂₁N₂O⁽¹⁺⁾*I^(1-)(1350474-91-7)
• EPA Substance Registry System: C₁₅H₂₁N₂O⁽¹⁺⁾*I^(1-)(1350474-91-7)

Safety Data

• Hazardous Substances Data: 1350474-91-7(Hazardous Substances Data)

Upstream product

• 276872-89-0 tert-butyl 3-methylidenepiperidine-1-carboxylate 
• 932-90-1 Benzaldoxime 
• 1350474-77-9 3-phenyl-7-methyl-1-oxa-2,7-diazaspiro[4.5]dec-2-ene 
• 74-88-4 methyl iodide 
• 1258322-86-9 3-phenyl-1-oxa-2,7-diazaspiro[4.5]dec-2-ene 
• 1258322-85-8 tert-butyl 3-phenyl-1-oxa-2,7-diazaspiro[4.5]dec-2-ene-7-carboxylate 

Relevant articles and documents

New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors

A set of structural analogues of spirocyclic quinuclidinyl- Δ2-isoxazolines, characterized as potent and selective α7 nicotinic agonists, was prepared and assayed for binding affinity at α7 and α4β2 neuronal nicotinic acetylcholine receptors (nAChRs). The investigated derivatives (3a-3c, 4a-4c, 5a-5c, 6a-6c, and 7a-7c), synthesized via the 1,3-dipolar cycloaddition of nitrile oxides to suitable dipolarophiles, showed an overall reduced affinity at the α7 subtype when compared with their model compounds. Solely Δ2-isoxazolines 3a, 3b, and 6c maintained a binding affinity in the nanomolar range at the α7 nAChRs (Ki = 230, 420 and 700 nM, respectively). The quaternary ammonium salt 6c retained also a noteworthy α7 vs. α4β2 subtype selectivity, whereas 3a and 3b showed a sharp reduction in selectivity compared with 1a and 1b, their quinuclidinyl higher homologues.