1350562-65-0

Upstream product

• 107-97-1 sarcosine 
• 153179-99-8 C₁₄H₂₀Br₂O₃ 

Downstream Products

• 1393086-75-3 biphenyl-4-yl 2-(((S)-4-bromo-2-((R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-5-oxo-2,5-dihydrofuran-3-yl)(methyl)amino)acetate 
• 1393086-83-3 4'-hydroxybiphenyl-4-yl 2-(((S)-4-bromo-2-((R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-5-oxo-2,5-dihydrofuran-3-yl)(methyl)amino)acetate 
• 1400891-41-9 4'-hexyloxybiphenyl-4-yl 2-(((S)-4-bromo-2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-5-oxo-2,5-dihydrofuran-3-yl)-N-methylamino)acetate 

Relevant academic research and scientific papers

Design and synthesis of 2(5H)-furanone liquid-crystal compounds based on natural molecules and biphenyl derivatives

Starting from natural molecules, for example l-menthol and amino acids, a series of 2(5H)-furanone liquid-crystal compounds were designed, and synthesized by esterification of N-[5-menthoxy-2(5H)-furanonyl] amino acids with biphenyl-4-ol or biphenyl-4,4′-diol in the presence of dehydrating agents. The structures of all the novel compounds were confirmed by FTIR, 1H NMR, and mass spectroscopy, and by elemental analysis. The liquid-crystal properties of the target compounds were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), and polarization optical microscopy (POM). The DSC and XRD results showed that some compounds containing short alkyl chains or with the phenyl far from the amino in the amino acid unit formed a mesomorphic phase. Products obtained from biphenyl-4,4′-diol were more likely to form a mesomorphic phase. However, POM revealed no optical texture. These investigations provide, for the first time, a basis for application of 2(5H)-furanones in liquid crystals by combination of different functional units, including biphenyl, l-menthol, and amino acids.

Synthesis and characterization of biphenyl liquid crystal based on natural molecules and 2(5H)-furanone moiety

Using 4′-hexyloxybiphenyl-4-ol and N-(5-alkoxy-3-bromo-2(5H)- furanonyl) amino acids as reactants, a series of novel biphenyl liquid crystal compounds containing natural molecule moieties, such as menthol, borneol, and amino acids, were synthesized via esterification. The structures of all novel compounds were confirmed by FTIR, 1H NMR, 13C NMR, MS, and elemental analysis, and the liquid crystal properties of target compounds were characterized with DSC, XRD, and POM. The introduction of hexyloxy made the biphenyl esters have a potential to appear in mesomorphic phase and have a higher Tm, and bornyl moiety was more beneficial for the liquid crystal performance than a menthyl unit. Most compounds were mesomorphic phase liquid crystal molecules, and POM and XRD showed that they existed in smectic phase. These researches provide a theoretical basis for the synthesis of biphenyl ester liquid crystal materials via the utilization of 2(5H)-furanone derivates and natural molecules.