135074-01-0

Upstream product

• 76617-78-2 2-(hydroxyimino)-4-methylpentanoic acid 
• 131828-26-7 5-amino-2-(benzyloxy)-6-(ethoxycarbonyl)-3-isobutylpyrazine 4-oxide 
• 131828-25-6 5-amino-6-(ethoxycarbonyl)-3-isobutyl-2(1H)-pyrazinone 4-oxide 
• 131828-24-5 N--2-(hydroxyimino)-4-methylpentanamide 
• 4502-00-5 sodium 4-methyl-2-oxovalerate 
• 158046-37-8 6-Benzyloxy-3-chloro-5-isobutyl-4-oxy-pyrazine-2-carboxylic acid methyl ester 
• 158046-36-7 5-amino-2-benzyloxy-3-isobutyl-6-methoxycarbonylpyrazine 4-oxide 
• 158046-35-6 5-amino-2-hydroxy-3-isobutyl-6-methoxycarbonylpyrazine 4-oxide 
• 100-39-0 benzyl bromide 
• 131828-35-8 2-benzyloxy-3-isobutyl-5-methoxy-6-methoxycarbonylpyrazine 4-oxide 
• 131828-27-8 5-amino-2-(benzyloxy)-6-(hydroxymethyl)-3-isobutylpyrazine 4-oxide 

Relevant academic research and scientific papers

AN ALTERNATIVE SYNTHESIS OF 2-BENZYLOXY-6-HYDROXYMETHYL-3-ISOBUTYL-5-METHOXYPYRAZINE 4-OXIDE, A KEY INTERMEDIATE FOR SYNTHESIS OF OPC-15161

2-Benzyloxy-6-hydroxymethyl-3-isobutyl-5-methoxypyrazine 4-oxide (5e), a key intermediate for synthesis of OPC-15161 (1a) having an inhibitory activity against superoxide anion generation, was prepared from 5-amino-2-benzyloxy-3-isobutyl-6-methoxycarbonylpyrazine 4-oxide (5b) by 3-step reaction.

The First Total Synthesis of OPC-15161

The first total synthesis of OPC-15161, a novel inhibitor of superoxide generation by guinea pig macrophages, has been accomplished via a convergent and efficient route exploiting the coupling of the fully functionalized pyrazine part with the indolyl gro