1350753-84-2Relevant academic research and scientific papers
Method for preparing 3-ketomorpholine
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Paragraph 0034; 0042; 0045-0046; 0052; 0055-0056; 0062-0076, (2019/03/26)
The invention relates to a method for preparing 3-ketomorpholine. The method comprises the following steps: protecting the amino group of ethanolamine firstly, then carrying out a reaction of amino group protected ethanolamine with alkyl haloacetate, performing deprotection on the prepared product, and performing ring closure so as to obtain 3-ketomorpholine. The method has the advantages of simple practical operation, low equipment requirements, high yield and low three waste, and is suitable for industrial large-scale production.
MAGL INHIBITORS
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Paragraph 0367; 0368, (2018/05/26)
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
Synthesis and binding properties of guanidinium biscarboxylates
Spaeth, Andreas,Gonschor, Janina,Koenig, Burkhard
experimental part, p. 1289 - 1308 (2012/06/15)
The ammonium ion binding site of the enzyme glutaminase HisF inspired us to design guanidinium biscarboxylates as potential self-organized ionophores in molecular recognition. The syntheses of the title compounds based on aliphatic and aromatic building b
