1350770-25-0

Basic information

• Product Name: 3-ethyl-1-methyl-4-phenylisoquinoline
• Synonyms: 3-ethyl-1-methyl-4-phenylisoquinoline
• CAS NO: 1350770-25-0
• Molecular Weight: 247.34
• Mol File: 1350770-25-0.mol

Chemical Properties

• CAS DataBase Reference: 3-ethyl-1-methyl-4-phenylisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl-1-methyl-4-phenylisoquinoline(1350770-25-0)
• EPA Substance Registry System: 3-ethyl-1-methyl-4-phenylisoquinoline(1350770-25-0)

Safety Data

• Hazardous Substances Data: 1350770-25-0(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 613-91-2 acetophenone oxime 
• 622-76-4 1-phenyl-1-butyne 

Relevant articles and documents

Cobalt(III)-Catalyzed Dehydrative [4+2] Annulation of Oxime with Alkyne by C-H and N-OH Activation

Efficient, scalable cobalt-catalyzed redox-neutral [4+2] annulation of readily available oximes and alkyne is reported. The developed synthetic methodology is widely applicable and tolerates various functional groups including heterocycles. A stable CpCoIII neutral complex is employed as the catalyst for this redox-neutral [4+2] annulation reaction, which progresses smoothly by way of a reversible cyclometallation without any external oxidizing agent, and produces only water as the side product.

Easy Access to 1-Amino and 1-Carbon Substituted Isoquinolines via Cobalt-Catalyzed C - H/N - O Bond Activation

A green atom-economical method for the synthesis of highly functionalized 1-amino and 1-carbon substituted isoquinolines from the reaction of N′-hydroxybenzimidamides and aryl ketoximes, respectively, with alkynes via pentamethylcyclopentadienylcobalt(III)-catalyzed C - H/N - O bond activation is described. The external oxidant-free annulation reaction uses the =NOH moiety in N′-hydroxybenzimidamides or N-aromatic ketone oximes as the directing group and internal oxidant. This first row transition metal-catalyzed annulation serves as an efficient alternative for the synthesis of isoquinolines, as water is the only by-product and expensive noble metals such as rhodium(III), iridium(III), palladium(II), and ruthenium(II) are not required. The reaction proceeds via C - H activation, alkyne insertion, reductive elimination, and N - O activation.

Pyridine synthesis from oximes and alkynes via rhodium(iii) catalysis: Cp* and Cpt provide complementary selectivity

The synthesis of pyridines from readily available α,β- unsaturated oximes and alkynes under mild conditions and low temperatures using Rh(iii) catalysis has been developed. It was found that the use of sterically different ligands allows for complementary selectivities to be achieved.