1350813-51-2Relevant articles and documents
Solid-phase synthesis of an apoptosis-inducing tetrapeptide mimicking the Smac protein
Le Quement, Sebastian T.,Ishoey, Mette,Petersen, Mette T.,Simonsen, Pernille M.,Holck, Nanna S.,Nielsen, Thomas E.
, p. 7049 - 7053 (2012/01/13)
An approach for the solid-phase synthesis of apoptosis-inducing Smac peptidomimetics is presented. Using a Rink linker strategy, tetrapeptides mimicking the N-4-terminal residue of the Smac protein [(N-Me)AVPF sequence] were synthesized on PEGA resin in excellent purities and yields. Following two synthetic routes, a known tetrapeptide, incorporating a substituted proline, previously shown to exhibit excellent biological activity in vitro as well as low toxicity, was synthesized effectively on a solid support.
