1350843-85-4

Basic information

• Product Name: 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone
• Synonyms: 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone
• CAS NO: 1350843-85-4
• Molecular Formula: C₁₆H₁₁ClO
• Molecular Weight: 254.71094
• EINECS: -0
• Mol File: 1350843-85-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 397.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone(1350843-85-4)
• EPA Substance Registry System: 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone(1350843-85-4)

Safety Data

• Hazardous Substances Data: 1350843-85-4(Hazardous Substances Data)

Usage

General Description

1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone, also known as 4'-chloro-2-ethynyl-2-biphenylcarbonyl chloride, is a chemical compound with a molecular formula C16H9ClO. It is a yellow solid at room temperature and is classified as an aryl ketone. 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethanone is used in the production of pharmaceuticals, agrochemicals, and dyes. It is also used as a reagent in organic synthesis and as a building block for the synthesis of various other compounds. The presence of a chlorine atom and a triple bond in its structure makes it a valuable intermediate in the synthesis of various biologically active compounds, making it an important chemical in the pharmaceutical and agrochemical industries.

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 2142-69-0 2-bromophenyl methyl ketone 
• 2142-70-3 2-iodoacetophenone 

Downstream Products

• 1338235-42-9 (E)-1-(2-((4-chlorophenyl)ethynyl)phenyl)-3-phenylprop-2-en-1-one 
• 1606161-27-6 12-methyl-5-(4-chlorophenyl)-6-(4-chlorobenzoyl)chrysene 

Relevant articles and documents

Palladium-catalyzed cascade decarboxylative amination/6- endo-dig benzannulation of o-alkynylarylketones with n-hydroxyamides to access diverse 1-naphthylamine derivatives

An efficient and practical one-pot strategy to produce highly substituted 1-naphthylamines via sequential palladium-catalyzed decarboxylative amination/intramolecular 6-endo-dig benzannulation reactions has been described. In this reaction, a broad range of electron-rich, electron-neutral, and electron-deficient o-alkynylarylketones react well with N-hydroxyl aryl/alkylamides to give a diversity of 1-naphthylamines in good to excellent yields under mild reaction conditions. The gram-scale synthesis, with benefits such as undiminished product yield and easy transformation, illustrated the practicality of this method.

Chemo- and Regioselective Catalyst-Controlled Carbocyclization of Alkynyl Ketones: Rapid Synthesis of 1-Indanones and 1-Naphthols

A catalyst-controlled intramolecular carbocyclization of 2-alkynyl aryl ketones is presented. Under rhodium(III) catalysis, 1-indanones are formed through 5-exo-dig carbocyclizations with exclusive chemo-, regio- and stereoselectivity. When catalyzed by copper(I), 1-naphthols are obtained through 6-endo-dig carbocyclizations with exclusive chemo- and regioselectivity.

Triflic acid-Mediated Expedient Synthesis of Benzo[a]fluorenes and Fluorescent Benzo[a]fluorenones

Fluorene-based polyaromatic hydrocarbons are renowned compounds for materials applications. Herein, a straightforward route via in situ acetal formation has been presented to access benzo[a]fluorenes by a triflic acid promoted cationic cycloisomerization