1350898-35-9Relevant academic research and scientific papers
Suzuki-Miyaura coupling reactions of iodo(difluoroenol) derivatives, fluorinated building blocks accessible at near-ambient temperatures
Wilson, Peter G.,Percy, Jonathan M.,Redmond, Joanna M.,McCarter, Adam W.
, p. 6384 - 6393 (2012/10/07)
A recently developed method for the near-ambient generation of difluorovinylzinc reagents has facilitated the preparation of 1-(N,N-diethylcarbamoyloxy)-2,2-difluoro-1-iodoethene and 2,2-difluoro-1-iodo-1- (2′-methoxyethoxymethoxy)ethene. The utility of these reagents has been investigated in Suzuki-Miyaura couplings with a range of potassium trifluoroborate coupling partners, with the scope of successful couplings proving wide. Deiodinated species appeared as significant side products, but a solvent change from i-PrOH to t-BuOH suppressed the pathway to these species and improved coupling yields.
One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol
Kyne, Sara H.,Percy, Jonathan M.,Pullin, Robert D. C.,Redmond, Joanna M.,Wilson, Peter G.
experimental part, p. 8328 - 8339 (2012/04/23)
Difluoroalkenylzinc reagents prepared from 1-(2′-methoxy- ethoxymethoxy)-2,2,2-trifluoroethane and 1-(N,N-diethylcarbamoyloxy)-2,2,2- trifluoroethane at ice bath temperatures underwent Negishi coupling with a range of aryl halides in a convenient one pot
